重症胰腺炎患者血淀粉酶、TNF-α、IL-1β和PCT在CRRT治疗后的变化和意义  

Effects and Significance of Serum Amylase,TNF-α,IL-1β and PCT in Patients with Severe Acute Pancreatitis After CRRT

作　　者：彭艳[1] 文刚[1] 彭雪刚[1] 谯明[1] 刘捷[1] 严婷[1] PENG Yan WEN Gang PENG Xue-gang QIAO Ming LIU Jie YAN Ting(Department of Critical Care Medicine, Renshou People＇s Hospital, Renshou 620500, Chin)

机构地区：[1]仁寿县人民医院ICU,四川仁寿620500

出　　处：《标记免疫分析与临床》2017年第9期1011-1014,共4页Labeled Immunoassays and Clinical Medicine

摘　　要：目的探讨重症胰腺炎患者应用连续性肾脏替代疗法(continuous renal replacement therapy,CRRT)治疗后体内血淀粉酶(blood amylase,AMY)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白细胞介素-1β(interleukin-1β,IL-1β)和降钙素原(procalcitonin,PCT)变化和意义。方法选取2015年8月至2017年5月期间,经本院确诊的重症胰腺炎患者80例并随机分为2组,每组40例。对照组给予常规临床治疗,观察组给予连续性肾脏替代疗法进行治疗。比较两组患者血清内血淀粉酶、TNF-α、IL-1β和PCT变化、两组患者的治疗效果及患者临床症状指标的变化。结果与对照组相比,观察组患者CRRT治疗后血清内血淀粉酶、TNF-α、IL-1β和PCT指标明显降低,患者主要临床症状指标的变化明显缓解(P<0.05)。与对照组相比,观察组CRRT治疗后总有效率显著升高,差异具有统计学意义(P<0.05)。结论 CRRT治疗重症胰腺炎能有效缓解患者的临床症状,并降低患者血清内血淀粉酶、TNF-α、IL-1β和PCT水平。Objective To investigate the effects and significance of serum amylase （AMY）, tumor necrosis factor-α （TNF-α）,Interleukin-1β, IL-1β and Procalcitonin （PCT） in patients with severe pancreatitis after continuous renal replacement therapy （CRRT）.Methods From August 2015 to May 2017, 80 patients with severe pancreatitis diagnosed by our hospital were randomly divided into two groups （n=40）.The control group was given routine clinical treatment, the observation group was given continuous renal replacement therapy for treatment.The changes of serum amylase, TNF-α, IL-1β and PCT were compared between the two groups, do did the treatment effects of two groups and the changes in clinical symptoms of patients.Results Compared with the control group, the levels of serum amylase, TNF-α, IL-1β and PCT were significantly decreased in the observation group after CRRT treatment.The changes of the main clinical symptoms were significantly relieved （P〈0.05）.Compared with the control group, the total effective rate of the CRRT group was significantly higher than that of the control group （P〈0.05）.Conclusion CRRT treatment of severe pancreatitis can relieve the clinical symptoms of patients and reduce the levels of serum amylase, TNF-α, IL-1β and PCT.

关 键 词：重症胰腺炎 连续性肾脏替代疗法 血淀粉酶 肿瘤坏死因子-α 白细胞介素-1Β 降钙素原 

分 类 号：R576[医药卫生—消化系统]