突触相关蛋白102的结构、功能及相关研究进展  

Structure,functions and relative diseases of synapse-associated protein 102

作　　者：苏东宁[1] 常丽荣[2] 武艳[2] SU Dong-ning CHANG Li-rong WU Yan(Grade 2012, Clinical Medicine of Undergraduate, Capital Medical University, Beijing 100069, China Department of Anatomy, Capital Medical University, Beijing 100069, China)

机构地区：[1]首都医科大学 [2]首都医科大学解剖学教研室,北京100069

出　　处：《解剖学报》2017年第5期628-632,共5页Acta Anatomica Sinica

摘　　要：突触相关蛋白102(SAP102)是突触后膜区域中一种重要的支架蛋白,属于膜相关鸟苷酸激酶家族(MAGUK),在新生和成熟的神经元中均有高表达。SAP102有助于特化结构域的受体,如N-甲基-D-天冬氨酸(NMDA)受体和α-氨基-3羟基-5甲基-4异恶唑(AMPA)受体和通道蛋白定位在特定膜区域上,并在囊泡内NMDA受体簇的胞质运输过程中起重要的调节作用。此外,SAP102还可参与调节皮质突触的发育。SAP102的表达或功能异常与多种疾病,如阿尔茨海默病与精神分裂症等的发生发展相关。尽管SAP102与神经系统正常生理功能及某些疾病关系密切,但目前人们对SAP102的认识尚不够充分,我们将对SAP102蛋白的结构、生理功能及与之相关疾病的研究进展进行综述。Synapse-associated protein 102 （SAP102） is a significant scaffold protein in postsynaptie density （PSD） and belongs to membrane-associated guanylate kinases （MAGUKs）. It is highly expressed in both neonatal and mature neurons. SAP102 plays an important role in the trafficking of NMDA receptor clusters in the vesicles, anchoring certain receptors and channel proteins on the membrane and regulating development of the synapses in the cortex. Abnormal changes of SAP102 are related to many diseases, such as Alzheimer＇ s disease and schizophrenia. Although it is crucial for both the normal biology functions of nervous system and the occurrence or development of certain diseases, the study of SAP102 is not enough. In this review, we focus on the structure, functions and relative diseases of SAP102.

关 键 词：突触相关蛋白102 膜相关鸟苷酸激酶家族 N-甲基-D-天冬氨酸受体 突触后致密区 

分 类 号：R31[医药卫生—基础医学]