中晚期前列腺癌术后化疗联合内分泌治疗的疗效及其与癌组织ER／3表达的相关性  

Effect of Postoperative Chemotherapy Combined with Endocrine Therapy on the Expression of ERβin Cancer Tissues of Advanced Prostate Cancer

作　　者：王进恩[1] 程帆 WANG Jin-en CHENG Fan(Xiaogan Central Hospital, Xiaogan ,Hubei, 432100, China)

机构地区：[1]孝感市中心医院,湖北孝感432100

出　　处：《医学临床研究》2017年第9期1684-1686,1690,共4页Journal of Clinical Research

摘　　要：【目的】探讨中晚期前列腺癌术后化疗联合内分泌治疗的疗效及其与癌组织ERB表达的相关性。【方法】收集2015年1月至2017年3月来本院就诊并接受手术切除治疗的中晚期前列腺癌患者120例，随机分为试验组和对照组，各60例。试验组术后给予化疗联合内分泌治疗，对照纽给予常规化疗治疗，观察两组患者治疗后疗效差异。并根据两组疗效差异分析治疗效果与癌组织ER0表达的相关性。【结果】试验组患者治疗后有效率明显高于对照组，差异有统计学意义（X2=9．219，P〈O．05）。试验组（n=60）、对照组（n=60）及两组共（n=120）治疗有效患者癌组织ERp表达水平评分均分别低于试验组、对照组及两组共治疗无效者，其差异亦有统计学意义（P〈O．05）。针对癌组织ERO表达水平与疗效进行单因素logistics回归分析，差异亦具有统计学意义（P〈0．05），癌组织ERj3的最大似然估计值和OR值均〈O，提示癌组织ERβ表达水平与疗效呈负相关。【结论】中晚期前列腺癌术后化疗联合内分泌治疗具有良好的疗效，且疗效与癌组织ER8表达呈明显负相关。[ObjectivelTo investigate the effect of postoperative chemotherapy combined with endocrine therapy on the advanced prostate cancer and the correlation of ERβ expression in cancer tissues.[MethodslA total of 120 patients with advanced prostate cancer were treated in our hospital from January 2015 to March 2017, and randomly divided into the ex- perimental group and the control group, 60 cases in each group. The experimental group received chemotherapy and en- docrine therapy, and the control group received routine chemotherapy. The curative effect difference between the two groups was observed. The correlation between the effect of treatment and the expression of ERi3 in cancer tissue was ana- lyzed according to the difference between the two groups. [Results] The effective rate of the prostate cancer patients in the experimental group was significantly higher than that of the control group, the difference was statistically significant （X2=9.219, P %0.05）. The expression levels of ERβ in cancer tissues were lower in the effective patients of experimental group, the control group and the two groups than those of ineffective patients. The difference was also statistically signifi- cant （ P 〈0.05）. According to the expression of ERβin cancer tissue level and efficacy of single factor logistics regression analysis, the differences were statistically significant （ P〈0.05）, the maximum likelihood estimates of cancer ERβand OR%0, which suggested that cancer ER beta expression levels were negatively correlated with the curative effect.[Con- clusionlPostoperative chemotherapy combined with endocrine therapy is effective in the treatment of middle and advanced prostate cancer. The effect is negatively correlated with the expression of ER βbeta in cancer tissues.

关 键 词：前列腺肿瘤/外科学 前列腺肿瘤/药物疗法 雄激素类/治疗应用 雌激素受体Β 

分 类 号：R737.25[医药卫生—肿瘤]