Syntaxin 8蛋白在胃癌组织中的表达及临床意义  

Study on expression of Syntaxin 8 protein in gastric carcinoma

作　　者：马丽 陈禹保[2] 薛建波 徐涛 仝建军 安云鹤[3] 

机构地区：[1]首都医科大学大兴教学医院消化科,北京102600 [2]北京市计算中心,北京100094 [3]北京市理化分析测试中心,北京100089

出　　处：《中国现代普通外科进展》2017年第7期535-538,共4页Chinese Journal of Current Advances in General Surgery

摘　　要：目的:探讨突触融合蛋白8(STX8)在胃癌组织中的表达及其临床意义。方法:收集62例胃癌患者术后胃癌及癌旁组织,采用免疫组织化学染色和Western blot方法检测STX8的蛋白表达,并分析STX8表达与胃癌临床病理的关系。结果:免疫组织化学结果显示,STX8在胃癌组织中阳性表达,在大部分癌旁胃组织中为阴性表达,差异有统计学意义(P<0.05);Western blot检测发现胃癌组织中STX8蛋白表达水平明显高于癌旁组织。相关分析发现syntaxin 8在胃癌组织中的高表达与患者性别、年龄、肿瘤大小、TNM分期及胃癌侵袭转移无关,但与发生远处转移相关。结论:STX8在胃癌组织中异常高表达,可能与胃癌的发生发展相关,也可能是潜在的胃癌分子诊疗靶点。Objective： To determine the expression of syntaxin 8 in gastric carcinoma and its clinical significance. Methods： To determine the expression levels of syntaxin 8 in gastric carcinoma and pericancerous stomach tissues of 62 patients with gastric carcinoma by immunohistochemistry, western blot. Results： Results of immunohistochemistry and western blot showed that the ex- pression of syntaxin 8 was significantly higher than that in the adjacent pericancerous stomach tissues, and syntaxin 8 is negative in most normal tissues. The difference was statistically significant （P〈0.05）. Correlation analysis found that the high expression of syntaxin 8 in gastric carcinoma tissue was not significantly related to gender, age, tumor size, TNM stage, invasion and metastasis of gastric carcinoma, but the higher expression rate was up-regulated in gastric carcinoma with distant metastasis. Conclusion： Syntaxin 8 is abnormal high expression in gastric carcinoma tissues, and is related to the occurrence and development of gastric carcinoma. It may also be a potential target for gastric carcinoma diagnosis and treatment.

关 键 词：胃癌 突触融合蛋白8 

分 类 号：R735.2[医药卫生—肿瘤]