543例大肠管状腺瘤性息肉及其癌变的临床特征分析  

Clinical analysis of 543 cases of colorectal tubular adenoma with malignant transformation

作　　者：孙东辉 Sun Donghui(Clinical School of Gansu University of Traditional Chinese Medicine,Lanzhou 730000,China Lanzhou General Hospital of PLA ,Lanzhou 730050, China)

机构地区：[1]甘肃中医药大学临床医学院,甘肃兰州730000 [2]解放军兰州总医院,甘肃兰州730050

出　　处：《甘肃医药》2017年第9期705-707,共3页Gansu Medical Journal

摘　　要：目的:探讨大肠管状腺瘤性息肉癌变的临床特点。方法:收集解放军兰州总医院内镜室2012年1月至2014年1月经病理证实大肠管状腺瘤性息肉543例患者的资料,其中发生癌变83例。回顾性分析543例管状腺瘤性息肉中发生癌变病例与性别、年龄、腺瘤大小、颗数、是否带蒂、发生部位、吸烟、饮酒、家族史、胆囊切除史、高脂血症的关系。结果:543例大肠管状腺瘤性息肉患者发生癌变83例,其中,男性管状腺瘤性息肉癌变率高于女性(P<0.05);60岁以上患者的管状腺瘤性息肉癌变率高于60岁以下(P<0.05);直径>2.0cm的管状腺瘤性息肉癌变率高于直径≤1.0cm及1.1～2.0cm管状腺瘤性息肉(P<0.05);颗数≥3的管状腺瘤性息肉癌变率高于1颗及2颗的管状腺瘤性息肉(P<0.05);有蒂、亚蒂及无蒂的管状腺瘤性息肉癌变率差异无统计学意义(P>0.05);发生在左半结肠的管状腺瘤性息肉癌变率高于右半结肠;吸烟、饮酒、有结肠癌家族史、胆囊切除史及高血脂患者发生管状腺瘤性息肉癌变的危险较高。结论:大肠管状腺瘤性息肉癌变率随着年龄、腺瘤的增大、颗数的增多而升高,且癌变率与发生部位、吸烟、饮酒、家族史、胆囊切除史、高脂血症有关。Objective：To investigate the clinical characteristics of colorectal tubular adenoma with cancerous polyps. Methods： We respectively analyzed the relationship of 543 cases of tubular adenoma polyps with sex,age,size of tumor,number of tumor,occurrence of pedicle,smoking,drinking,alcohol,family history,history of cholecystectomy and hyperlipidemia. Results：In all cases,colorectal tubular adenoma with cancerization among 543 was 83 cases,of which the rate of colorectal tubular adenoma with cancerization in male patient was high than females＇ ; the rate of colorectal tubular adenoma with cancerization in patients over 60 years old is higher than 60 years of age （P〈0.05）; the rate of diameter 〉2.0cm tubular adenomatous polyp canceration is higher than the diameter is less than or equal to 1 0cm and 1.1-2 0cm tubular adenomatous polyp （P〈0.05）; a number of more than 3 of malignant tubular adenomatous polyp was higher than 1 and 2 tubular adenomatous polyps（P〈0.05）; There was no significant difference in the incidence of malignant transformation of tubular adenoma with pedicle, Iati and sessile.（PM）.05）; carcinogenesis in tubular adenomatous polyps of the left colon was higher than that of the right colon cancer; smoking, drinking,family history of colon cancer,history of cholecystectomy and hyperlipemia in patients with tubular adenomatous polyps was higher than whom without the above factors. Conclusions：the rate of colorectal tubular adenoma with cancerization increased with age,Enlargement of adenoma, the number of adenoma,and the incidence of colorectal cancer was related to the place of occurrence,smoking,drinking,family history,history of cholecystectomy and hyperlipidemia.

关 键 词：大肠腺瘤性息肉 癌变率 临床特点 

分 类 号：R73[医药卫生—肿瘤]