丹七软胶囊辅助治疗对急性出血性脑血管病患者血清炎性因子、凝血功能及血液流变学指标的影响  

Effect of Dan seven soft capsule adjuvant therapy on serum inflammatory factors,coagulation function and blood rheology indexes in patients with acute hemorrhagic cerebrovascular disease

作　　者：桂树华 胡玲玲 王挺刚 眭晨燕 殷晓菁 孔亮 

机构地区：[1]无锡市中西医结合医院神经内科,江苏无锡214000

出　　处：《海南医学院学报》2017年第16期2278-2281,共4页Journal of Hainan Medical University

基　　金：江苏省卫生厅科研项目(P201512)~~

摘　　要：目的:探讨丹七软胶囊辅助治疗急性出血性脑血管病,对患者血清炎性因子、凝血功能及血液流变学指标的影响。方法:112例急性出血性脑血管病患者,依据随机数据表法分为对照组(n=57)和观察组(n=55),对照组患者在常规治疗基础上给予依达拉奉治疗,观察组患者在对照组患者治疗基础上再给予丹七软胶囊治疗。比较两组患者治疗前后血清炎性因子、凝血功能及血液流变学指标水平。结果:治疗前,两组患者炎性因子高敏C反应蛋白(hs-CRP)、肿瘤坏死因子α(TNF-α)和白介素-6(IL-6)、凝血功能纤维蛋白原(FIB)、凝血酶原时间(PT)及部分凝血酶原时间(APTT)和血液流变学指标(高切全血黏度、低切全血粘度及血浆黏度)水平比较,差异无统计学意义(P>0.05);治疗后,两组hs-CRP、TNF-α、IL-6、FIB、高切全血黏度、低切全血黏度及血浆黏度水平较组内治疗前,其水平均显著降低,差异有统计学意义(P<0.05),且观察组治疗后hs-CRP、TNF-α、IL-6、FIB、高切全血黏度、低切全血黏度及血浆黏度水平均显著低于对照组,差异有统计学意义(P<0.05);与组内治疗前相比,治疗后两组的PT及APTT水平均显著升高(P<0.05),且观察组显著高于对照组,差异有统计学意义(P<0.05)。结论:丹七软胶囊辅助治疗急性出血性脑血管病,可有效降低患者血清炎性因子水平,改善其凝血功能及血液流变学指标,具有重要临床价值。Objective：To investigate the effect of Dan seven soft capsule on the treatment of acute hemorrhagic cerebrovascular disease and the influence of serum inflammatory factors,coagulation function and blood rheology indexes.Methods：A total of 112 patients with acute hemorrhagic cerebrovascular disease were divided into the control group（n=57）and observation group（n=55）according to the random data table：the patients in the control group received routine treatment combined with edaravone,and on the basis of the treatment of the control group,the observation group was treated with Dan seven soft capsule.The serum levels of inflammatory factors,coagulation function and blood rheology indexes were compared between the two groups before and after treatment.Results：Before treatment,there were no significant difference in the inflammatory factors（hs-CRP,TNF-αand IL-6）,blood coagulation function（FIB,PT and APTT）and hemorheology（high cut whole blood viscosity,low cut whole blood viscosity and plasma viscosity）levels between the control group and observation group.Compared with the levels of the same group before treatment,two groups of hs-CRP,TNF-α,IL-6,FIB,high cut whole blood viscosity,low cut whole blood viscosity and plasma viscosity levels after treatment were significantly decreased（P〈0.05）,and levels in the observation group were significantly lower than those in the control group（P〈0.05）.Compared with the group before treatment,the levels of PT and APTT in the two groups were significantly increased（P〈0.05）,and the observation group was significantly higher than the control group（P〈0.05）.Conclusion：Dan seven soft capsule in the treatment of acute hemorrhagic cerebrovascular disease can effectively reduce the level of serum inflammatory factors,improve coagulation function and blood rheology index,and it has an important clinical value.

关 键 词：急性出血性脑血管病 丹七软胶囊 炎性因子 凝血功能 血液流变学 

分 类 号：R743.3[医药卫生—神经病学与精神病学]