早期康复训练联合依达拉奉对脑出血患者氧自由基生成、神经损伤程度的影响  

Effect of early rehabilitation training on oxygen free radical generation and nerve injury in patients with cerebral hemorrhage

作　　者：刘昭淑 周霞[1] 

机构地区：[1]四川省自贡市第三人民医院神经内科,四川自贡643020

出　　处：《海南医学院学报》2017年第16期2282-2284,2288,共4页Journal of Hainan Medical University

基　　金：四川省卫生厅科研项目(150823)~~

摘　　要：目的:研究早期康复训练联合依达拉奉对脑出血患者氧自由基生成、神经损伤程度的影响。方法:选择在本院就诊的56例急性脑出血患者并随机分为早期康复组和常规康复组,早期康复组脑出血病情稳定2天后开始进行康复训练、常规康复组脑出血后14d开始进行康复训练。脑出血后28、56d时,分别检测血清中氧自由基、神经损伤标志物、神经营养分子的含量。结果:脑出血后28、56d时,早期康复组患者血清中MDA、AOPP、8-OHdG、GFAP、NSE、Tf、Ft、S100B的含量均显著低于常规康复组,BDNF、NGF、NTF-α、IGF-I的含量均显著高于常规康复组。结论:早期康复训练联合依达拉奉用于脑出血能够抑制氧自由基生成、减轻神经损伤程度并改善神经营养状态。Objective：To study the effect of early rehabilitation training combined with edaravone on oxygen free radical generation and nerve injury in patients with cerebral hemorrhage.Methods：A total of 56 patients with acute cerebral hemorrhage who were treated in Zigong Third People＇s Hospital were selected and randomly divided into early rehabilitation group and routine rehabilitation group,the early rehabilitation group began the rehabilitation training 2days after cerebral hemorrhage condition was stabilized,and routine rehabilitation group began the rehabilitation training 14 days after cerebral hemorrhage.Serum contents of oxygen free radicals,nerve injury markers and neurotrophic molecules were detected 28 days and 56 days after cerebral hemorrhage.Results：Twenty-eight days and fifty-six days after cerebral hemorrhage,serum MDA,AOPP,8-OHdG,GFAP,NSE,Tf,Ft and S100 Blevels of early rehabilitation group were significantly lower than those of routine rehabilitation group,while BDNF,NGF,NTF-αand IGF-I levels were significantly higher than those of routine rehabilitation group.Conclusion：Early rehabilitation training combined with edaravone for cerebral hemorrhage can inhibit the oxygen free radical generation,reduce the degree of nerve injury and improve the neurotrophic state.

关 键 词：脑出血 依达拉奉 早期康复训练 氧自由基 神经营养 

分 类 号：R743.34[医药卫生—神经病学与精神病学]