肺腺癌患者的EGFR基因突变与PET/CT的18F-FDG摄取值的相关性研究  

Correlation between EGFR gene mutation and uptake value of 18F-FDG of PET/CT in patients with lung adenocarcinoma

作　　者：王峥[1] 司婧文 迟明友 石珍亮[1] 徐医军[1] 张逊[1] 

机构地区：[1]天津市胸科医院胸外科,天津300350 [2]天津市中心妇产科医院病理科,天津300199

出　　处：《转化医学电子杂志》2017年第9期32-35,共4页E-Journal of Translational Medicine

基　　金：国家重点专科;天津市科技计划项目(17YFZCSY00850)

摘　　要：目的:探讨EGFR基因突变与PET/CT中病灶的SUV最大值之间的相关性.方法:回顾性分析天津市胸科医院胸外科Linkdoc数据库中2015-01-01/2016-06-30在治疗前同时接受了PET/CT检查和EGFR基因检测的61例肺腺癌患者.探究EGFR基因突变与患者各项临床特征以及SUV最大值之间的相关性,并进行了多变量逻辑回归分析.结果:EGFR基因突变患者的SUV最大值(5.39±4.35)明显低于EGFR基因野生型患者的SUV最大值(9.98±5.46),差异有统计学意义(P<0.001).ROC曲线提示SUV最大值的临界值为6.8,AUC为0.72(95%可信区间0.59-0.84).多变量逻辑回归分析结果显示,性别以及SUV最大值对EGFR基因的突变起着重要的预测作用.结论:对于无法获得组织学病理的肺腺癌患者来说,PET/CT的SUV最大值和性别对于EGFR基因突变有着重要的预测价值.AIM： To predict the correlation between EGFR gene mutation and maximum standardized uptake value（ SUVmax） of PET/CT. METHODS： A total of 61 patients with lung adenocarcinoma undergoing EGFR mutation testing and pretreatment positron emission tomography/computed tomography（ PET/CT）admitted into Tian Jin Chest Hospital from January 2015 to June2016 were selected as objects of study. The relationship of EGFR gene mutations with both SUVmax and patients＇ characteristics were evaluated,and a multivariate logistic regression analysis was performed. RESULTS： The SUVmax values were significantly lower in EGFR gene mutations patients（ 5.39±4.35） than those of EGFR gene wild-type（ 9. 98 ± 5. 46）,with statistically significant difference（ P〈0.001）. ROC curve analysis showed that the critical value of SUVmax was 6.8,for which the AUC was 0.72（ 95%CI,0.59-0. 84）. In addition,multivariate analysis also showed that SUVmax and gender were predictors of EGFR gene mutations.CONCLUSION： The specific FDG uptake value could be considered to effectively predict EGFR gene mutation status of patients with adenocarcinoma when genetic tests are not available.

关 键 词：EGFR突变 SUV PET/CT 肺腺癌 

分 类 号：R734.2[医药卫生—肿瘤]