结直肠癌放疗敏感性相关分子生物学标记研究进展  

Advances in sensitive biomarkers of radiotherapy in colorectal cancer patients

作　　者：许聪 曹科[1] 刘兰 吴慧[1] 田瑞芳 曹培国[1] 黄程辉[1] 

机构地区：[1]中南大学湘雅三医院肿瘤科,长沙410013

出　　处：《转化医学电子杂志》2017年第9期84-87,共4页E-Journal of Translational Medicine

基　　金：中南大学创新驱动项目(2017CX012);湖湘青年人才项目(2016RSRCHX0076)

摘　　要：结直肠癌是目前世界上高发病率肿瘤之一,结直肠癌的治疗以手术为主,必要时联合放疗、化疗及靶向治疗.放疗在结直肠癌的治疗中占有重要地位,然而临床上有部分患者对放疗不敏感甚至放疗抵抗.肿瘤细胞的放射敏感性与细胞氧合、细胞周期、增殖活性、DNA损伤修复等多种因素相关.本文主要从凋亡相关基因、转录因子蛋白、抗氧化蛋白、表皮生长因子受体、非编码RNA及自噬相关基因等方面对结直肠癌放疗敏感性相关分子生物学标记研究进展进行综述.High incidence all over the world,the treatments are chiefly divided into surgery or surgery combined with radiotherapy,chemotherapy and targeted therapy if necessary. Radiation therapy plays an important role in the comprehensive treatment of colorectal cancer. However, some patients are not sensitive or even resistant to radiotherapy. The radiosensitivity of tumor cells is affected by cell oxygenation,cell cycle,proliferative activity,DNA damage repair and other related factors. Herein,we outlined the advances in sensitive biomarkers of radiotherapy in colorectal cancer,mainly involving the apoptosis-related genes,transcription factor protein,antioxidant protein,epidermal growth factor receptor,non-coding RNA and autophagy-related genes.

关 键 词：结直肠癌 放疗敏感性 分子生物学标记 

分 类 号：R735.34[医药卫生—肿瘤]