基于磁定位三维超声-超声单模态融合成像技术评估肝肿瘤消融范围的实验研究  

Assessment of ablation zone of liver tumor by 3DUS-US fusion imaging based on electromagnetic positioning：an experimental study

作　　者：吕淑敏[1] 练荣丽[2] 龙颖琳[1] 苏中振 郑荣琴[1] 许尔蛟[1] Lyu Shumin Lian Rongli Long Yinglin Su Zhongzhen Zheng Rongqin Xu Erjiao(Department of Ultrasound, Guangdong Key Laboratory of Liver Disease Research, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China)

机构地区：[1]中山大学附属第三医院超声科,广东省肝脏疾病研究重点实验室,广州510630 [2]中山大学附属第三医院综合ICU,广州510630 [3]中山大学附属第五医院超声科,广州510630

出　　处：《中华超声影像学杂志》2017年第9期803-807,共5页Chinese Journal of Ultrasonography

基　　金：国家自然科学基金（81430038,81401434）;广东省科技计划项目（2014A020212136,2015A020214009,2017A020215082）;广东省医学科研基金（A2015257）;梅州市科技计划项目（20158083）

摘　　要：目的通过体外模型实验研究，探讨基于磁定位三维超声一超声单模态融合成像技术评估肝肿瘤消融范围的可行性及准确性。方法建立16个可用于消融及评估消融范围的体外模型，随机将模型分为完全消融组和不完全消融组（各8个）。利用三维超声一超声单模态融合成像技术评估肿瘤消融是否完全；对于不完全消融者，测量肿瘤残留的最大厚度。以大体标本结果作为“金标准”，验证该技术评估的可行性及准确性。记录配准成功率、融合操作时间、评估消融是否完全的准确率及不完全消融组的测量误差。结果16个体外模型均建模成功，三维超声一超声单模态融合成像技术的配准成功率为100％，融合操作时间为（3．9±1．0）min，评估消融是否完全的准确率为100％，不完全消融组肿瘤残瘤厚度的超声与大体标本测量值差异无统计学意义（t=-0．814，P=0．442），测量误差为（1．1±0．6）mm。结论基于磁定位三维超声-超声单模态融合成像技术评估肝肿瘤消融范围是可行的，准确性高且操作简便。有望成为肝肿瘤消融术中即时精准疗效评估的新方法。Objective To investigate the feasibility and accuracy of three-dimensional ultrasound- ultrasound （3DUS-US） fusion imaging based on electromagnetic positioning in the assessment of ablation zone of liver tumor through experimental study in phantom models. Methods Sixteen phantom models which could be ablated and used to assess the ablation zone were established. Then, they were ablated and divided into complete ablation group （ n = 8） and incomplete ablation group （ n = 8） randomly. Their ablation effects were assessed by 3DUS-US fusion imaging. If the tumor model was assessed as incomplete ablation, the maximum thickness of the residual tumor was measured. The assessments of gross specimen were used as golden standard to validate the feasibility and accuracy of assessment of 3DUS-US fusion imaging. The success rate of registration, duration time of fusion imaging, accuracy rate of assessment and measurement error in incomplete ablation group were recorded. Results All of the 16 phantom models were produced successfully. The success rate of registration was 100% and the duration time of 3DUS-US fusion imaging was （3.9 ± 1.0）min. The accuracy rate of assessment was 100%. There was no significant difference between the assessment of residual tumor thickness in incomplete ablation group by 3DUS-US fusion imaging and gross specimen （ t = - 0. 814, P = 0. 442）, and the measurement error was （1.1 ± 0.6） mm. Conclusions 3DUS-US fusion imaging based on electromagnetic positioning is a feasible, accurate and convenient method in the assessment of ablation zone of liver tumor. It would be a new immediate precise assessment method during ablation procedure for liver tumor.

关 键 词：超声检查 消融技术 图像融合 电磁定位 

分 类 号：R445.1[医药卫生—影像医学与核医学]