CXCL12-CXCR4/CXCR7生物轴在肝癌中的研究进展  

Advances of CXCL12-CXCR4/CXCR7 Biological Axis in Hepatocellular Carcinoma

作　　者：李妍晨 华宗荣 刘瑶[2] 黄才斌[2] LI Yanchen HUA Zongrong LIU Yao HUANG Caibin(The First Clinical Medical College of Gannan Medical University, Ganzhou 341000, China Department of Gastroenterology, The First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, China)

机构地区：[1]赣南医学院第一临床医学院,赣州341000 [2]赣南医学院第一附属医院消化内科,赣州341000

出　　处：《肿瘤防治研究》2017年第9期636-640,共5页Cancer Research on Prevention and Treatment

基　　金：国家自然科学基金(81160257;81660406);江西省卫计委科技计划项目(20161096);江西省科技厅重点研发计划项目(20161BBG70232);赣州市指导性科技计划项目(GZ2015ZSF072);赣南医学院校级课题(ZD201601);赣南医学院研究生创新课题(YC-2016-X007)

摘　　要：肝细胞癌(hepatocellular carcinoma,HCC)是世界上发病率和死亡率最高的恶性肿瘤之一。研究发现,CXCL12-CXCR4/CXCR7生物轴可通过自分泌和(或)旁分泌机制调控HCC细胞的生长、血管生成、免疫逃逸及侵袭转移等关键步骤,有可能成为HCC防治新靶点和预后评价新标志。本文就当前国内外研究CXCL12-CXCR4/CXCR7生物轴在肝癌发生和发展过程中的作用以及与此相关的信号转导途径进行综述。Hepatocellular carcinoma（HCC） is one of the malignant tumors with the highest morbidity and mortality rates in the world.Studies have shown that CXCL12-CXCR4/CXCR7 biological axis can modulate the growth of HCC cells,angiogenesis,immune escape,invasion and metastasis via autocrine and/or paracrine mechanisms,and may become a new therapeutic target and valuable prognostic marker for HCC.This review aims to summarize the multiple functions of CXCL12-CXCR4/CXCR7 axis in HCC development and progression,as well as the signal transductions that are essential to this process.

关 键 词：肝细胞癌 CXCL12 CXCR4 CXCR7 

分 类 号：R735.7[医药卫生—肿瘤]