通腑化痰活血法对脑梗死急性期患者抗凝血酶Ⅲ前列环素、血栓素A_2的影响  

Effects of Dredging Fu Organs,Dispersing Phlegm and Activating Blood Method (通腑化痰活血法) on Antithrombin Ⅲ,Prostacyclin,Thromboxane A_2 Levels in Patients with Acute Cerebral Infarction

作　　者：王彩红[1] 史春和 牛兴茹 王玉肖[1] WANG Caihong SHI Chunhe NIU Xingru WANG Yuxiao(People＇s Hospital of Tang County, Tang County ,Hebei 07235)

机构地区：[1]河北省唐县人民医院,河北唐县072350

出　　处：《中国中医药科技》2017年第5期561-563,共3页Chinese Journal of Traditional Medical Science and Technology

基　　金：河北省保定市科学技术研究与发展指导计划(15ZF023)

摘　　要：目的:观察通腑化痰活血法治疗脑梗死急性期患者的疗效及其对抗凝血酶Ⅲ(AT-Ⅲ)、前列环素(PGI_2)、血栓素A_2(TXA_2)的影响。方法:92例脑梗死急性期患者随机分为观察组和对照组,2组均予以西医常规治疗,观察组在此基础上加用通腑化痰活血方治疗,观察2组的临床疗效和治疗前后日常生活能力评分指数(Barthel指数)、血浆AT-Ⅲ、6-keto-PGF1α、TXB_2的变化情况。结果:观察组疗效优于对照组(P<0.05);观察组治疗后Barthel指数上升程度较对照组明显(P<0.05)。2组治疗后血浆AT-Ⅲ、6-keto-PGF1α水平较治疗前明显提高(P<0.05或P<0.01),TXB_2水平较治疗前明显下降(P<0.05);观察组改善程度优于对照组(P<0.05)。结论:通腑化痰活血法可提高脑梗死急性期患者的治疗效果,改善患者日常生活能力,其作用机制与纠正高凝状态、抑制血栓形成有关。Objective： To observe the curative effect of dredging fu organs, dispersing phlegm and activating blood method on acute cerebral infarction and effects on antithrombin III, prostacyelin, thromboxane A2. Methods： 92 patients with acute cerebral infarction were randomly divided into observation group and control group, the two groups were treated with routine Western medicine, the observation group was given dredging fu organs , dispersing phlegm and activating blood Fang on the basis of the control group, they were treated for 30 days,then the curative effect was evaluated and the changes of daily living ability score index（ Barthel index）, plasma AT - III, 6 - keto -PGF1 alpha, TXB2 levels were observed before and after treatment. Results： The curative effect of the observation group was better than that of the control group （P 〈 0. 05）. The degree of Bar- thel index increased in the observation group was more significant than that of control group （ P 〈 0. 05 ）. The lev- els of AT -III and 6 - keto - PGF1 cdn the two groups were significantly improved compared with those before treatment （P 〈0. 05 or P 〈0. 01）, the level of TXB2 was significantly decreased （P 〈0. 05）, the effects of the observation group were better than those of the control group （ P 〈 0. 05 ）. Conclusion： Dredging fu organs, dis- persing phlegm and activating blood method have significant effect on cerebral infarction in acute stage, and could improve the daily living ability of the patients, the mechanism may be correct hypereoagulable state, inhib- iting thrombus formation.

关 键 词：通腑化痰活血法 脑梗死急性期 抗凝血酶Ⅲ 前列环素 血栓素A2 大承气汤 三化汤 

分 类 号：R277.7[医药卫生—中医学]