Hebei Province Natural Science:Based on The Xuan Fu Theory to Explore Sanhua Tang on Ischemic Stroke Blood-brain Barrier Protection Mechanism Research(No.H2022423327);Science and Technology Program of Hebei Provincial Administration of Traditional Chinese Medicine:based on The Changes in Gut Microbiota,Explore Sanhua Tang From The Perspective of"Opening the Xuan Fu"Protective Phlegm Heat Relieving Excess Syndrome of Ischemic Stroke Mechanism of Action of the Blood-brain Barrier(No.2022090);Hebei Key Laboratory of Chinese Medicine Research on Cardio-cerebrovascular Disease in 2021 Project:Based on the Gut-brain Axis,Explore Sanhua Tang's Treatment of Ischemic Stroke Syndrome(Phlegm Heat Relieving Empirical Model)(No.2021201);the Innovation Funding Program for Doctoral Students in Hebei Province:the Mechanism Research of Sanhua Tang Regulating Gut Microbiota,Improving the Blood-brain Barrier Damage of Ischemic Stroke(No.CXZZBS2022095);National College Students'Innovation and Entrepreneurship Training Program:Based on the Xuan Fu Theory to Explore Sanhua Tang on Ischemic stroke Blood-brain Barrier Protection Mechanism Research(No.202114432005);Special Project on the Cultivation of Scientific and Technological Innovation Ability of College and Middle School Students in Hebei Province:Mechanism Research of Bushen Huoxue Fang on Synaptic Plasticity in the Hippocampal Nerve After Vascular Dementia through Phosphatidylinositide 3-Kinase/Protein Kinase b/Mammalian Target of Rapamycin Signaling Pathways(22E50142D)。
OBJECTIVE:To assess the effect and mechanism of Sanhua Tang(三化汤,SHT)in treating ischemic stroke(IS)through the"Kaitong Xuanfu"theory by using network pharmacology and animal experiments.METHODS:The active ingredien...