急性脑梗死患者血浆TNF-α和IL-10变化的临床意义研究  

Clinical Studies of Plasma TNF-α and IL-10 Expression in Patients with Acute Cerebral Infarction

作　　者：李广文 赵海苹 马青峰[2] 鞠飞 王荣亮 范志彬 罗玉敏 Li Guangwen Zhao Haiping Ma Qingfeng Ju Fei Wang Rongliang Fan Zhibin Luo Yumin(Cerebrovascular Diseases Research Institute Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China)

机构地区：[1]首都医科大学宣武医院脑血管病研究室 [2]首都医科大学宣武医院神经内科,北京100053

出　　处：《生命科学仪器》2017年第4期32-35,21,共5页Life Science Instruments

基　　金：国家自然科学基金面上项目(81471340;81571280)

摘　　要：目的:探讨急性脑梗死患者肿瘤坏死因子-α(TNF-α)和白介素10(IL-10)在血浆中的表达变化及表达变化的临床意义。方法:收集33例急性脑梗死患者为观察组,24例健康人为对照组,检测两组血浆中TNF-α和IL-10的表达水平,并收集观察组患者血常规、生化指标、凝血指标、脑梗死体积、入院时的NIHSS评分和治疗7天后的m RS评分,分析TNF-α和IL-10水平与以上临床参数的相关性。结果:脑梗死发生6小时内,TNF-α水平明显升高,与对照组比较差异具有统计学意义(p<0.05);且TNF-α对脑梗死的诊断具有较高的诊断价值;血浆TNF-α和IL-10呈正相关,与患者发病7天后的m RS评分呈负相关关系;血浆IL-10与白细胞的数量呈负相关,与脑梗死体积、血小板平均体积(MPV)、血小板分布宽度(PDW)和血糖(GLU)呈正相关关系。结论:TNF-α在脑梗死急性期显著升高,对脑梗死具有较高的诊断价值,且TNF-α和IL-10表达水平与多项临床参数有关。Objective： To investigate the changes of plasma tumor necrosis factor-or （TNF-α） and interleukin 10 （IL-10） expression and their relationship with clinical parameters in acute cerebral infarction. Methods： 33 acute cerebral infarct patients were in the observation group, 24 healthy people were in control group. Detecting the expression of plasma TNF-a and IL-10 in two groups, and collect the parameters of blood routine, biochemical detection, blood coagulation index, cerebral infarction volume, NIHSS score and mRS score in the observation group, and then analysis the correlation between TNF-α, IL-10 level and the above clinical parameters. Results： TNF-α levels increased significantly in cerebral infarction patients within 6 hours, the difference was statistically significant compared with the control group （P 〈 0.05）; a high diagnostic value of TNF-α in the diagnosis of cerebral infarction; plasma TNF-α was positively correlated with IL-10; the TNF-α level was negative correlated with the mRS score at 7 days after stroke onset; there was a negative correlation between plasma IL-10 and the number of leukocytes; mean platelet volume （MPV）, platelet distribution width （PDW） and blood glucose （GLU） were positively correlated with IL-10 level. Conclusion： The expression of TNF-α in acute cerebral infarction increased within 6 hours, and has a higher diagnostic value for cerebral infarction. The expression levels of TNF-α and IL-10 are related to various clinical parameters in acute cerebral infarction.

关 键 词：脑梗死 TNF-Α IL-10 临床参数 

分 类 号：R743.3[医药卫生—神经病学与精神病学]