西宁地区汉、藏、回族非酒精性脂肪性肝病患者血清瘦素、脂联素水平及其临床意义  

The Level and Clinical Significance of Serum Leptin and Adiponectin in Patients with Non-Alcoholic Fatty Liver in Xining Area

作　　者：马臻棋 赵彬[1] 王学红 Ma Zhenqi Zhao Bin Wang Xuehong(Digestion Internal Medicine Department The Affiliated Hospital of Qinghai University （810001)

机构地区：[1]青海大学附属医院消化内科,810001

出　　处：《青海医药杂志》2017年第5期2-5,共4页Qinghai Medical Journal

摘　　要：目的:通过检测西宁地区非酒精性脂肪性肝病(NAFLD)患者血清瘦素、脂联素水平,分析体重指数(BMI)、胰岛素抵抗指数(HOMA-IR)与瘦素和脂联素之间的关系,探讨NAFLD的发病机制。方法:选取世居于西宁地区2013年6月—2015年6月期间,在我院住院确诊的NAFLD患者55例作为研究对象,测定空腹血糖、空腹胰岛素、瘦素和脂联素,测算BMI和HOMA-IR,并对NAFLD患者按民族进行分组观察。结果:NAFLD患者中回族血清瘦素水平和HOMA-IR高于汉族和藏族(均P<0.01),汉族HOMA-IR高于藏族(P<0.01);NAFLD患者中汉、藏、回族血清瘦素水平与BMI均呈正相关(均P<0.01),汉族和回族血清瘦素与HOMA-IR之间呈正相关(P<0.01);NAFLD患者中,回族血清脂联素水平与BMI呈负相关(P<0.01);NAFLD患者中,回族血清瘦素与脂联素呈负相关(P<0.05)。结论:血清瘦素、脂联素水平异常参与了NAFLD的发病机制,而西宁地区NAFLD患者血清瘦素、脂联素水平与胰岛素抵抗、肥胖关系密切,另外,民族差异可能影响NAFLD发生。Objective： By testing serum leptin and adiponectin levels in patients with nonalcoholic fatty liver disease （NAFLD） in Xining area, we analyze the relationship between body mass index （BMI）, insulin resistance index （HOMA--IR）, leptin and adiponectin, and explore the pathogenesis of NAFLD.Methods：We Selected the native NAFLD 55 patients who were diagnosed in our hospital during from June in 2013 to June in 2015 as the observation group, whose FBG, Fins, leptin and adiponectin levels were measured, and BMI and HOMA--IR of whom were calculated. Meanwhile, the NAFLD patients were observed according to different ethnic groups.Results： The levels of serum leptin and HOMA--IR of the Hui Nationality were higher than the Tibetan and the Has Nationality（P〈0.01）, and HOMA--IR of the Has Na- tionality was higher than that of the Tibetan （P〈0.01） in the NAFLD patients.In the NAFLD patients, serum leptin levels were positively correlated with BMI in the Han, Tibetan and Hui Nationalities （P〈0.01）. The Han and Hui Nationalities＇ serum leptin and HOMA--IR were positively correlated （P〈0.01）.In the NAFLD patients, the level of serum adiponectin and BMI showed negative correlation in Hui Nationalities（P〈0.01）.In the NAFLD patients, the Hui Nationalities＇ serum leptin and adiponectin showed negative correlation （P〈0.05）.Conclusions：Serum levels of leptin and adiponectin abnormality are involved in the pathogenesis of NAFLD, and in Xining area the serum leptin in patients with NAFLD, serum adiponectin levels and insulin resistance, obesity are closely related. In addition, the ethnic differences may affect on NAFLD.

关 键 词：非酒精性脂肪性肝病 瘦素 脂联素 胰岛素抵抗 

分 类 号：R575.5[医药卫生—消化系统] R195.4[医药卫生—内科学]