三项指标检测对食管癌术后早期吻合口瘘的诊断价值  

Diagnostic value of three index in diagnosing early postoperative anastomotic fistula of duct cancer

作　　者：王艳霞 王玉艳[2] 

机构地区：[1]胜利石油管理局胜北社区肛肠病防治院检验科,山东东营257077 [2]胜利油田中心医院检验科,山东东营257034

出　　处：《检验医学与临床》2017年第19期2882-2884,共3页Laboratory Medicine and Clinic

摘　　要：目的分析血清降钙素原(PCT)、C反应蛋白(CRP)与清蛋白(ALB)检测对食管癌术后早期吻合口瘘的诊断价值。方法选取284例食管癌术后患者,分为早期吻合口瘘组(AL组)84例,非吻合口瘘组(非AL组)200例。针对两组患者的手术前及术后的状况,分析血清PCT、CRP与ALB的水平变化趋势对诊断效果的影响及对食管癌术后早期吻合口瘘的诊断效果。结果术后两组血清PCT水平变化比较差异有统计学意义(P<0.05)。AL组血清PCT水平第5天达到峰值,差异有统计学意义(P<0.01),上升迅速。两组术后的血清PCT持续3~4d下降达到最低值,AL组保持在低水平,非AL组水平缓慢回升。以术后第5天CRP水平作为预测指标,两组都维持在较高水平,组间比较差异无统计学意义(P>0.05)。结论食管癌术后血清PCT水平迅速升高,CRP维持高水平不下降同时ALB持续低水平的患者吻合口瘘发生率高,吻合口瘘发生的风险大。血清PCT、CRP与ALB检测有助于食管癌术后早期吻合口瘘的诊断,帮助患者加快恢复健康。Objective To analyze the diagnostic value of serum procalcitonin（PCT）,C-reactive protein（CRP）and albumin（ALB）in early postoperative anastomotic fistula of duct cancer.Methods A total of 284 postoperative cases of duct carcinoma were selected and divided into the anastomotic fistula group（AL group,84cases）and non-anastomotic fistula group（non-AL group,200cases）.The change trend of serum PCT,CRP and ALB levels and their influence on diagnostic effect by aiming at preoperative and postoperative status and on early diagnostic effect was evaluated.Results The serum PCT level change had statistical difference between the two groups（P〈0.05）.The serum PCT level on postoperative 5din the AL group reached the peak value with statistical difference（P〈0.01）,and the elevation was rapid.Serum PCT level was continuously decreased for 3-4d,and reached the lowest level,which in the AL group maintained the low level,which in the AL group was risen slowly.The CRP level on postoperative 5dserved as the predictive index,the two groups all maintained the higher level,but the inter-group comparison had no statistical difference（P〉0.05）.Conclusion The duct cancer patients with serum PCT rapid increase,CRP high level without decrease and ALB continuous low level have higher occurrence rate of anastomotic fistula and big risk of anastomotic fistula occurrence.The early postoperative diagnosis of serum PCT,CRP and ALB in anastomotic fistula is conducive to help patients accelerate recovery healthy.

关 键 词：吻合口瘘 血清降钙素原 C反应蛋白 清蛋白 

分 类 号：R735.1[医药卫生—肿瘤]