腹腔镜手术联合新辅助化疗对宫颈癌患者三项血清标志物的影响  

Effect of laparoscopic surgery combined with neoadjuvant chemotherapy on the three serum markers in patients with cervical cancer

作　　者：高立[1] 刘妍[1] 

机构地区：[1]陕西省宝鸡市妇幼保健院妇科,721000

出　　处：《检验医学与临床》2017年第19期2897-2899,2903,共4页Laboratory Medicine and Clinic

摘　　要：目的观察腹腔镜手术联合新辅助化疗对宫颈癌患者血清糖类抗原(CA125)、癌胚抗原(CEA)和鳞状细胞癌抗原(SCC-Ag)的影响。方法选择2013年1月至2016年6月在该院进行诊治的宫颈癌患者92例,根据治疗方法的不同,将新辅助化疗后行腹腔镜宫颈癌根治术的患者46例作为观察组,直接进行手术的46例患者作为对照组。对比不同临床分期宫颈癌患者血清肿瘤标志物阳性率及手术相关因素,比较两组患者手术前后CA125、CEA及SCC-Ag水平。结果治疗前不同临床分期宫颈癌患者血清CA125、CEA和SCC-A水平,Ⅰ期患者的阳性率明显低于Ⅱ期患者,两组患者在盆腔淋巴结转移、淋巴脉管间隙浸润、宫颈间质浸润深度、手术时间及宫颈阴道旁组织宽度等比较,差异有统计学意义(P<0.05);治疗前后对比,两组患者的CA125、CEA和SCC-Ag水平均明显降低,治疗后观察组患者的CA125、CEA和SCC-Ag水平下降更明显,差异有统计学意义(P<0.05)。结论腹腔镜手术联合新辅助化疗治疗宫颈癌可明显降低患者的CA125、CEA和SCC-Ag水平。具有广泛的临床应用前景。Objective To observe the effect of laparoscopic surgery combined with neoadjuvant chemotherapy on serum carbohyrate antigen 125（CA125）,carcinoembryonic antigen（CEA）and squamous cell carcinoma antigen（SCC-Ag）in the patients with cervical cancer.Methods Ninety-two patients with cervical cancer diagnosed and treated in the hospital from January 2013 to June2016were selected and divided into the two groups according to the different treatment methods.Forty-six cases of laparoscopic cervical cancer radical operation after neoadjuvant chemotherapy served as the observation group.Forty-six cases directly conducting operation served as the control group.The levels of serum CA125,CEA and SCC-Ag before and after operation were compared between the two groups.Results In the levels of serum CA125,CEA and SCC-Ag before treatment,their positive rate in the patients with stageⅠ was significantly lower than that in the patients with stageⅡ.The pelvic lymph node metastasis,lymphatic vessel interstitial infiltration,cervical interstitial infiltration depth,operation time and cervical paracolpium tissue width had statistical difference between the two groups（P〈0.05）;the levels of CA125,CEA and SCC-Ag after treatment in the two groups were significantly decreased compared with those before treatment,but the decrease of CA125,CEA and SCC-Ag level after treatment in the observation group was more significant,the difference was statistically significant（P〈0.05）.Conclusion Laparoscopic surgery combined with neoadjuvant chemotherapy in the treatment of cervical cancer can significantly reduce the levels of CA125,CEA and SCCAg and has extensively clinical application prospects.

关 键 词：腹腔镜手术联合新辅助化疗 宫颈癌 血清肿瘤标志物 

分 类 号：R737.33[医药卫生—肿瘤]