纤维乳腺导管镜下碘染色对导管内增生性病变的诊断研究  

Diagnostic accuracy of fiberoptic ductoscopy plus iodine staining for intraductal proliferative lesions

作　　者：独晓燕[1] 马秀芬[1] 毛红岩[1] 隆建萍[1] 

机构地区：[1]甘肃省妇幼保健院乳腺科,甘肃兰州730050

出　　处：《国外医学（医学地理分册）》2017年第3期259-261,共3页Foreign Medical Sciences：Section of Medgeography

基　　金：兰州市科学技术局的社会发展(医药卫生)项目(2015-2-30)

摘　　要：目的探讨纤维乳腺导管镜下碘染色对导管内增生性病变的作用。方法纳入2015年10月至2017年6月因乳头溢液来本院就诊患者180例,随机分为两组,观察组(n=90)行FDS下碘染色,对照组(n=90)仅行常规FDS检查。对可疑病变定位后手术切除并行病理检查,以病理结果为金标准,比较两种方法对导管内增生性病变的诊断价值。结果观察组和对照组对导管上皮内瘤变(DIN)的诊断符合率分别为96.43%和80%。观察组的敏感性,特异性和约登指数分别为97.82%、80%、0.764;对照组的相应值分别为86.74%、55.56%、0.355。观察组的灵敏度,特异度和诊断符合率均显著高于对照组。结论 FDS下碘染色对DIN的诊断优于常规FDS,有助于乳腺癌的诊断。Objective To investigate the effectiveness of fiberoptic ductoscopy （FDS） plus iodine staining in the diagnosis of intraductal proliferative lesions. Methods The clinical data of 180 patients with nipple discharge treated during Jan. 2015 and June 2017 were randomly divided into two groups. The observation group （n = 90） was subjected to iodine staining under FDS, while the control group （n = 90） received routine FDS only. Suspected cases then underwent operation, and the specimens were examined histopathologically. The diagnostic value of the two methods for ductal intraepithelial neoplasm （DIN） was then compared. Results The diagnostic accordance rate of the observation group and control group was 96.43% and 80%, respectively. The sensitivity, specificity and Youden index of the observation group were 97.82%, 80% and 0. 764, while those of the control group were 86.74%, 55.56% and 0. 355. The parameters of the observation group were significantly higher than those of the control group. Conclusion Iodine staining under FDS is superior to conventional FDS in the detection of DIN, which is helpful in the diagnosis of breast cancer.

关 键 词：纤维乳腺导管镜 乳腺导管增生性病变 诊断 

分 类 号：R737.9[医药卫生—肿瘤]