神经元特异烯醇化酶、胃泌素释放肽前体与小细胞肺癌病情变化的相关性研究  

Clinical study on the relationship between neuron specific enolase,pro-gastrin-releasing peptide and the changes of conditions in small cell lung cancer patients

作　　者：段桦[1] 崔慧娟[1,2] 彭艳梅[1] 宋亚中 刘戴维 刘凡[1] 邱钰芹[1] 李嫱[1] 罗楚凡 

机构地区：[1]北京中医药大学中日友好临床医学院,北京100029 [2]中日友好医院中西医结合肿瘤内科,北京100029

出　　处：《中日友好医院学报》2017年第5期279-282,共4页Journal of China-Japan Friendship Hospital

基　　金：首都临床特色应用研究专项(Z151100004015168)

摘　　要：目的:观察小细胞肺癌(SCLC)患者病情变化时(肿瘤治疗有效或进展)神经元特异烯醇化酶(NSE)、胃泌素释放肽前体(ProGRP)的变化情况,研究二者的敏感性和与病情变化的一致性。方法:回顾性分析2013年1月~2016年12月在中日友好医院住院治疗的47例SCLC患者病历,记录其临床特征及病情变化前后NSE、ProGRP,进行统计分析。结果 :确诊时不同性别、年龄、吸烟史患者NSE、ProGRP水平无统计学差异(均P>0.05),广泛期患者均高于局限期患者(均P<0.05);当肿瘤治疗有效时,NSE、ProGRP水平均显著下降(均P<0.05);肿瘤进展时,ProGRP显著升高(P<0.05);肿瘤治疗有效时,NSE、ProGRP的变化符合率均为100%,中位下降度分别为70.59%、85.11%;肿瘤进展时,NSE、ProGRP变化符合率均为86%,中位上升率分别为128.57%、86.12%。结论 :NSE、ProGRP可以作为预测SCLC临床分期的辅助标志物;NSE、ProGRP均可反映病情变化,但ProGRP比NSE更灵敏;在SCLC的临床诊治中应加强对NSE、ProGRP的检测。Objective ：To evaluate the relationship and consistency between the levels of neuron specific eno- lase （NSE）,pro-gastrin releasing peptide （PoGRP）and the changes （remission or progression）of conditions in small cell lung cancer patients by observing the variations of NSE and ProGRP levels.Methods：Clinical data including serum NSE and ProGRP levels of forty-seven SCLC patients that were treated in China-Japan Friendship Hospital were analyzed retrospectively.Results：At the beginning of diagnosis,serum NSE,ProGRP in patients with extensive diseases were significantly higher than those with limited diseases （P〈0.05）.The levels of NSE and ProGRP were significantly decreased when the disease were undercontrolled（P〈0.05）.The levels of ProGRP were significantly increased when the disease trolled,the consistency rates of NSE and ProGRP were progressed （P〈0.05）.When the disease were undercon- both 100% and the median decline rates were 70.59% and 85.11% ,respectively.When the disease progressed,the consistency rates of NSE and ProGRP were both 86% and the median rise rates were 128.57% and 86.12%,respectively.Conclusion：NSE and ProGRP can be used as the markers to predict the clinical stage;the levels of ProGRP and NSE can be used as condition monitoring indicators and ProGRP maybe superior to NSE.We should strengthen the detection of NSE and Pro- GRP in patients of SCLC during their diagnosis and treatment.

关 键 词：小细胞肺癌 病情变化 神经元特异烯醇化酶 胃泌素释放肽前体 

分 类 号：R734.2[医药卫生—肿瘤]