ⅢA（N2）期非小细胞肺癌术后预后因素分析  

Analysis of the influencing factors of the prognosis of patients with stage ⅢA （N2） non small cell lung cancer

作　　者：岳卫平[1] Yue Weiping(Department of Respiratory Medicine, Heft Hospital Affiliated of Changzhi Medical College, Changzhi 046011, China)

机构地区：[1]长治医学院附属和济医院呼吸内科,山西长治046011

出　　处：《中国实用医刊》2017年第18期1-3,共3页Chinese Journal of Practical Medicine

摘　　要：目的研究ⅢA（N2）期非小细胞肺癌（NSCLC）患者术后预后相关影响因素。 方法选取214例ⅢA（N2）期NSCLC患者为研究对象，对其完整的临床资料进行回顾性分析，总结术后预后主要影响因素。 结果214例NSCLC患者的中位生存期仅为26.48个月，1年生存率为83.57%，3年生存率为25.39%，5年生存率为7.28%；ⅢA（N2）期NSCLC患者术后N2包膜是否完整、N2转移组数、N2分期、T分期、手术方式、肿瘤体积、肿瘤距断端距离及术后是否接受化疗等指标在5年生存率方面比较差异有统计学意义（P〈0.05）；经多因素回归分析，ⅢA（N2）期NSCLC术后预后危险因素主要是：N2转移组数、N2分期、T分期、肿瘤体积、肿瘤距断端距离及术后接受化疗，且N2包膜完整性属于预后保护因素。 结论ⅢA（N2）期NSCLC具有比较低的术后生存率，且预后不理想；术后预后主要影响因素包括肿瘤体积大、术后化疗、T分级高、N2分期为ⅢA2～ⅢA3、N2包膜缺乏完整性、肿瘤距断端〈1 cm及N2淋巴结转移组超过1组等。ObjectiveTo study the related influence factors of the prognosis of patients with stage ⅢA（N2） non small cell lung cancer （NSCLC）.MethodsTwo hundred and fourteen patients with stage ⅢA（N2） NSCLC were selected as the study subjects, and the clinical data were retrospectively analyzed. The main influence factors of the prognosis were summarized.ResultsThe median survival time of the 214 patients with NSCLC was 26.48 months, and the 1-year, 3-year and 5-year survival rates were 83.57%, 25.39% and 7.28% respectively. The 5-year survival rates had significant differences in patients with stage ⅢA（N2） NSCLC and whether the N2 capsule was complete, the number of N2 metastasis groups, N2 stage, T stage, operation methods, tumor volume, distance from tumor to the broken end and whether or not to receive chemotherapy after operation （P〈0.05）. Multivariate regression analysis showed that the risk factors of the prognosis of stage ⅢA（N2） NSCLC included number of N2 metastasis groups, N2 stage, T stage, operation methods, tumor volume, distance from tumor to the broken end and postoperative chemotherapy while the integrity of N2 capsule was the protective factor of prognosis.ConclusionsThe survival rate of patients with stage ⅢA（N2） NSCLC is relatively lower after operation, and the prognosis is not ideal. The main influencing factors including tumor volume, postoperative chemotherapy, high T stage, N2 stage ⅢA2-ⅢA3, lack of integrity of N2 capsule, distance from tumor to the broken end 〈 1 cm and the number of N2 lymph node metastasis groups more than 1 group.

关 键 词：预后因素分析 非小细胞肺癌 肺癌术后 NSCLC 多因素回归分析 肿瘤体积 3年生存率 LC患者 

分 类 号：R734.2[医药卫生—肿瘤]