高、低剂量 131I在甲状腺癌术后残留组织去除中的应用效果  

Application effect of high and low doses of 131I in removal of residual tissue after thyroidectomy

作　　者：詹芳勇 李凤玲[1] 徐凌忠[2] The People＇s Hospital of Shouguang Shouguang China(Tang FY, Li FL School of Public Health, Shandong University, Ji＇ nan 250012, China（ Xu LZ)

机构地区：[1]山东省寿光市人民医院,262700 [2]山东大学公共卫生学院,济南250012

出　　处：《中国实用医刊》2017年第18期45-48,共4页Chinese Journal of Practical Medicine

摘　　要：目的探讨高剂量（100～120 mCi）与低剂量（30～40 mCi）131I在去除甲状腺癌术后残留组织中的应用效果。 方法选择行外科手术治疗的甲状腺癌患者94例，采用随机数字表及随机余数分组法分为观察组和对照组，每组47例。观察组给予空腹一次性口服131I 30～40 mCi，对照组给予空腹一次性口服131I 100～120 mCi，去除甲状腺癌术后残留组织6个月后比较两组疗效及不良反应发生率。 结果服用131I治疗6个月后，观察组与对照组去除甲状腺癌术后残留组织成功率（53.19%比51.06%）、唾液腺功能紊乱发生率（4.26%比6.38%）、颈部疼痛的发生率（4.26%比4.26%）比较差异未见统计学意义（P〉0.05）；两组促甲状腺激素[（14.23±5.27）μU/ml比（23.18±6.44）μU/ml]、甲状旁腺激素[（22.38±6.14）ng/L比（27.16±7.32）ng/L]、甲状腺球蛋白[（1.12±0.11）pg/L比（1.63±0.24）pg/L]、胃肠道反应发生率（4.26%比1.28%）、泪腺功能紊乱发生率（2.13%比17.02%）比较差异有统计学意义（P〈0.05）。 结论高剂量与低剂量131I去除甲状腺癌术后残留组织效果相当，但低剂量131I可以降低不良反应的发生率。To investigate the application effect of high dose （100-120 mCi） and low dose （30-40 mCi） of 131I on removing the postoperative residual tissue of thyroid carcinoma. MethodsNinety-four thyroid carcinoma patients underwent surgical treatment were selected, according to random number table and random remainder grouping, they were divided into observation group and control group, with 47 cases in each group. The patients in observation group were given oral 131I 30-40 mCi in fasting state, at one time, and the patients in control group were given oral 131I 100-120 mCi in fasting state. The curative effects and the incidences of adverse reactions between the two groups were compared after six months of removal of residual tissue after thyroidectomy. ResultsAfter 6 months, the success rate of removal of residual tissue （53.19% vs 51.06%）, the incidence of salivary gland dysfunction （4.26% vs 6.38%）, the incidence of neck pain （4.26% vs 4.26%） between the observation group and control group had no significant difference （P〉0.05）. The differences of thyroid-stimulating hormone [（14.23±5.27）μU/ml vs （23.18±6.44）μU/ml], parathyroid hormone [（22.38±6.14）ng/L vs （27.16±7.32）ng/L], thyroglobulin [（1.12±0.11）pg/L vs （1.63±0.24）pg/L], gastrointestinal reaction rate （4.26% vs 1.28%） and lacrimal gland dysfunction rate （2.13% vs 17.02%） between the two groups were significant （P〈0.05）. ConclusionsThe effects of high dose and low dose of 131I on removing the postoperative residual tissue of thyroid carcinoma are comparable, but the low dose of 131I can reduce the incidence of adverse reactions.

关 键 词：甲状腺癌 碘-131 术后残留组织去除 高低剂量 

分 类 号：R736.1[医药卫生—肿瘤]