Foxc对颅颌面骨组织发育的调控作用  

Regulation of Forkhead Box C Genes on Craniomaxillofacial Bone Tissue Development

作　　者：司家文[1] 沈国芳[1] 郭礼和[2] Si Jiawen Steve G.F. Shen Guo Lihe(Department of Oral and Maxillofacial Surgery, Ninth People＇s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China)

机构地区：[1]上海交通大学医学院附属第九人民医院口腔颅颌面科,上海200011 [2]中国科学院上海生命科学研究院生物化学与细胞生物学研究所,上海200031

出　　处：《中国细胞生物学学报》2017年第9期1251-1254,共4页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:81600827;81570947)资助的课题~~

摘　　要：Foxc(forkhead box C)基因在人、鼠等多个物种间高度保守,其亚家族成员Foxc1基因和Foxc2基因参与了细胞内多条重要信号转导通路,与人体神经、骨骼、循环系统的发育和功能密切相关。近年来的研究表明,Foxc1基因和Foxc2基因在颅颌面组织发育过程中发挥着重要的调控作用,可能共同参与了极为复杂的牙和颅颌面骨组织发育调控网络。该文就近年来Foxc基因对颅颌面骨组织发育过程的调控作用研究进展进行综述,以期为相关领域研究的开展提供参考。The forkhead box C（Foxc） genes are highly conserved in various species such as humans and rodents. The subfamily members of Foxc genes, namely Foxc1 and Foxc2, which have been proven to be participated in several important signal transduction pathways, and are closely related to the development and function of the human neural, skeletal and circulatory system. Recent studies have suggested that Foxc1 and Foxc2 may play an important and cooperative role in regulation of the development of the craniomaxillofacial bone tissue and teeth. In this paper, the research progress of the regulation of Foxc genes on craniomaxillofacial bone tissue development is reviewed.

关 键 词：FOXC1 FOXC2 颅颌骨 颅颌面畸形 骨骼发育 

分 类 号：R782[医药卫生—口腔医学]