基于主成分分析法对冠心病痰湿证理化指标的权重研究  

Study on Weight of Physical and Chemical Index of Phlegm-damp Pattern of Coronary Heart Disease Based on Principal Component Analysis

作　　者：段飞[1] 胡镜清[2] Duan Fei Hu Jingqing(First Affiliated Hospital of Henan University of TCM,Zhengzhou 450000,China Institute of Basic Theory for Chinese Medicine,China Academy of Chinese Medicine Science,Beijing 100700,China)

机构地区：[1]河南中医药大学第一附属医院,郑州450000 [2]中国中医科学院中医基础理论研究所,北京100700

出　　处：《世界中医药》2017年第9期1989-1992,共4页World Chinese Medicine

基　　金：国家重点基础研究发展计划(973计划)项目(2014CB542903);国家重大新药创制科技重大专项课题(2013ZX09303301)--"中药新药临床研究技术平台规范建设";中国中医科学院中医基础理论研究所第九批自主选题研究生项目(YZ-1545)

摘　　要：目的:研究冠心病痰湿证与一些理化检查指标的相关性,及其对诊断冠心病痰湿证的重要程度。方法:构建冠心病痰湿证的理化指标调查问卷,采用德尔菲法进行现场问卷调查,根据专家打分结果,采用基于主成分分析法结合综合构建评价函数,确定冠心病痰湿证理化指标权重。结果:冠心病痰湿证的相关理化指标权重顺序:超声心动图(0.188)>冠脉造影(0.161)>血糖(0.142)>炎性反应因子(0.118)>C反应蛋白(0.108)>血脂(0.103)>同型半胱氨酸(0.090)>脂蛋白(0.076)>血尿酸(0.015)。结论:超声心动图、冠脉造影、血糖、炎性反应因子、C反应蛋白、血脂占冠心病痰湿证诊断理化指标中80%的权重,对冠心病痰湿证的诊断具有重要意义。Objective： To study the correlations between pathogenesis physical and chemical examination results and phlegm-damp pattern of coronary heart disease（ CHD）,and its importance for diagnosis of phlegm-damp pattern of CHD. Methods： Questionnaire of physical and chemical indicators of phlegm-damp pattern of CHD was developed,and questionnaire survey on the spot was conducted by Delphi method. Based on expert questionnaire results,evaluation function was constructed based on principal component analysis to determine the weight of physical and chemical indexes of phlegm-damp pattern of CHD. Results： The weight sequence of physical and chemical indexes of phlegm-damp pattern of CHD was as follows： ultrasonic cardiogram（ 0. 188） 〉 coronary angiogram（ 0. 161） 〉 blood sugar（ 0. 142） 〉 inflammation factors（ 0. 118） 〉 CRP（ 0. 108） 〉 blood lipids（ 0. 103） 〉 HCY（ 0. 090） 〉 lipoprotein（ 0. 076） 〉 uric acid（ 0. 015）. Conclusion： Ultrasonic cardiogram,coronary angiogram,blood sugar,inflammation factors,CRP,blood lipids account for 80% of weight of physical and chemical index of phlegm-damp pattern of CHD,which has great significance in the diagnosis of phlegm-damp pattern of CHD.

关 键 词：主成分分析法 冠心病 痰湿证 

分 类 号：B541.4[哲学宗教—外国哲学] R311[医药卫生—基础医学]