浅谈冠心病痰瘀互结证及内质网自噬在冠心病痰瘀互结证中的研究意义  

Discussion on Significance of Coronary Heart Disease with Phlegm and Blood Stasis Pattern and Endoplasmic Reticulum Autophagy's Influence During its Process

作　　者：王琛 胡镜清[1] Wang Chen Hu Jingqing(Institute of Basic Theory for Chinese Medicine, China Academy of Chinese Medicine Science, Belting 100700, China)

机构地区：[1]中国中医科学院中医基础理论研究所,北京100700

出　　处：《世界中医药》2017年第9期2009-2013,共5页World Chinese Medicine

基　　金：国家重点基础研究发展计划(973计划)项目(2014CB542903)--"基于冠心病痰瘀互结证辨证方法的创新研究";国家重大新药创制科技重大专项课(2013ZX09303301)--"中药新药临床研究技术平台规范建设";中国中医科学院中医基础理论研究所基本科研业务费自主选题项目(YZ-1678)

摘　　要：痰浊、瘀血为冠心病主要病理基础,痰瘀互结贯穿冠心病发生发展始终,本文首先从病因病机、治法方药及现代生物学基础等方面浅谈冠心病痰瘀互结证,在冠心病痰瘀互结证的现代生物学基础中,细胞凋亡为影响冠心病最终转归、预后的重要因素,而内质网自噬是调节细胞凋亡的重要机制,本文以细胞凋亡为切入点,初探内质网自噬在冠心病痰瘀互结证中的研究意义。Phlegm turbidity and blood stasis are main pathogenesis basis for coronary heart disease（ CHD）,and play a key role in the whole process of CHD. This article firstly discussed CHD with phlegm and blood stasis pattern from its etiology,pathogenesis,treatment and biological basis. Among the biological basis,apoptosis influences the outcome and prognosis of CHD and endoplasmic reticulum autophagy（ ER-phagy） is the key point to regulate apoptosis. Therefore this article investigated its role in the CHD with phlegm and blood stasis pattern from apoptosis.

关 键 词：痰瘀互结证 冠心病 内质网自噬 细胞凋亡 

分 类 号：R22[医药卫生—中医基础理论]