2-氨基甲基-3-氯-5-三氟甲基吡啶盐酸盐的合成  

Synthesis of 2-Aminomethyl-3-Chloro-5-(Trifluoromethyl) Pyridine Hydrochloride

作　　者：陆阳[1] 陶京朝[2] 周志莲 张志荣[4] Lu Yang Tao Jingzhao Zhou Zhilian Zhang Zhirong(Office of Organic chemistry, Xinyang Agriculture College, Xinyang Henan 464000, China Chemistry Department of ZhengZhou University, Zhengzhou Henan 450001, China New Drag Research and Development Center Henan KeYi Group, Xinyang Henan 464000, China Henan FuBang Pesticides Chemical Engineering Company, Xinyang Henan 464000, China)

机构地区：[1]信阳农林学院有机化学教研室,河南信阳464000 [2]郑州大学化学系,河南郑州450001 [3]河南科易集团新药研究开发中心,河南信阳464000 [4]河南富邦农药化工公司,河南信阳464000

出　　处：《农药科学与管理》2017年第9期16-21,共6页Pesticide Science and Administration

摘　　要：旨在寻找一条适用于工业化生产的合成2-氨基甲基-3-氯-5-三氟甲基吡啶盐酸盐的新路线。以2,3-二氯-5-三氟甲基吡啶为起始原料,经过亲核取代反应,得到反应物;再与10%HCl水溶液经过亚胺水解、脱羧"一锅法"反应制得目标化合物2-氨基甲基-3-氯-5-三氟甲基吡啶盐酸盐。反应总收率为79.4%,纯度为99.6%,所有中间体及产物经IR和1H NMR进行表征。该合成技术收率较高,经济合理,操作简单,为工业化生产奠定了基础。This article aims to establish a new manufacturing process suitable for the industrial production of 2 - aminomethyl - 3 - chloro - 5 - （trifluoromethyl） pyridine hydrochloride. （I） was synthesized through a nucleophilic substitution reaction using 2, 3 - dichloro - 5 - trifluoromethyl - pyridine as raw material. Then （I） and 10% Hydrochloric solution went through ＂one -pot＂ reac- tion of hydrolysis of imine and decarboxylic to produce target compound of 2 - aminomethyl - 3 - ehloro -5 - （trifluoromethyl） pyridine hydrochloride. The total yield was 79.4% and the purity of product was 99.6%. The structure of the final product and all the intermediates were confirmed by IR and 1H NMR. This synthetic technology has advantages of high yield, reasonable cost and simpie operation, which laid the foundation for industrial production

关 键 词：2 3-二氯-5-三氟甲基吡啶 水解 脱羧 

分 类 号：TQ450.6[化学工程—农药化工]