A novel bone marrow targeted gadofullerene agent protect against oxidative injury in chemotherapy  

一种新型靶向骨髓的金属富勒烯用于防护化疗造成的氧化损伤（英文）

作　　者：张莹 舒春英 甄明明 李杰 于童 贾旺 李雪 邓睿君 周悦 王春儒 

机构地区：[1]Beiiing National Laboratory for Molecular Sciences,Key Laboratory of Molecular Nanostructure and Nanotechnology,CAS Research/Education Center for Excellence in Molecular Sciences,Institute of Chemistry,Chinese Academy of Sciences,Beijing 100190,China [2]University of Chinese Academy of Sciences,Beijing 100049,China

出　　处：《Science China Materials》2017年第9期866-880,共15页中国科学（材料科学（英文版）

基　　金：financially supported by the National Natural Science Foundation of China(51472248,51372251 and 51502301);the National Major Scientific Instruments and Equipments Development Project(ZDYZ2015-2);the Key Research Program of the Chinese Academy of Sciences(QYZDJ-SSW-SLH025,KGZD-EWT02 and XDA09030302)

摘　　要：Chemotherapy as an effective cancer treatment technique has been widely used in tumor therapy. However, it is still a challenge to overcome the serious side effects of chemotherapy, especially for its myelotoxicity. Here we report a novel strategy using the water soluble gadofullerene nanocrystals（GFNCs） to protect against chemotherapy injury in hepatocarcinoma bearing mice, which was induced by the commonly chemotherapeutic agent cyclophosphamide（CTX）.The GFNCs were revealed to specifically accumulate in the bone marrow after intravenously injecting to mice and they exhibited excellent radical scavenging function, resulting in a prominent increase of mice blood cells and pathological improvements of the primary organs in the GFNCs（15 mg kg-（-1））treated mice after the CTX（60 mg kg-（-1）） therapy. Moreover,the GFNCs maintained and even strengthened the antineoplastic activity of the CTX agent. Therefore, the GFNCs would be the promising chemoprotective agents in chemotherapy based on their high efficiency, low toxicity and metabolizable property.本文报道了一种利用金属富勒烯纳米材料实现肿瘤化疗骨髓保护的新技术.肿瘤化疗往往会带来严重的骨髓抑制等毒副作用,给患者造成极大的创伤.利用金属富勒烯纳米材料高效清除自由基、高选择性且快速富集在小鼠骨髓中的特性,开发了基于金属富勒烯的新型化疗辅助药物.研究表明,金属富勒烯实现了多方面的化疗保护效果,对白细胞计数最高可提升166%,对淋巴细胞最高可提升285%,对于骨髓以及脾脏多器官均有显著保护效果,且未影响化疗药物的肿瘤治疗效果.该材料是一种快速、高效、毒副作用小的新型肿瘤化疗辅助药物,具有巨大的发展潜力.

关 键 词：gadofullerene nanocrystals chemopreventive agent MYELOSUPPRESSION radical scavenging chemotherapy drug 

分 类 号：R730.5[医药卫生—肿瘤] TB383.1[医药卫生—临床医学]