幽门螺杆菌在胰腺癌发生发展中作用的研究进展  

Research progress of role of Helicobacter pylori on oncogenesis and progression of pancreatic cancer

作　　者：曹成亮[1] 曲凤智 王刚[1] 孙备[1] 

机构地区：[1]哈尔滨医科大学附属第一医院胰胆外科,哈尔滨150001

出　　处：《中国普外基础与临床杂志》2017年第10期1275-1278,共4页Chinese Journal of Bases and Clinics In General Surgery

基　　金：国家自然科学基金项目(项目编号:81370565);哈尔滨医科大学于维汉院士杰出青年基金

摘　　要：目的探讨幽门螺杆菌与胰腺癌发生发展之间的关系。方法收集近年来国内外有关幽门螺杆菌与胰腺癌关系的文献并进行综述。结果幽门螺杆菌感染在胰腺癌发生发展中发挥某种作用。幽门螺杆菌在胰腺癌患者中的感染率高于健康对照组,且在幽门螺杆菌抗体阳性者中细胞毒素相关基因A阴性的幽门螺杆菌阳性率高于健康对照组。结论幽门螺杆菌感染与胰腺癌的发生发展可能有一定的关系,但其具体机制仍不明确,还需要进一步研究。Objective To study effects of Helicobacter pylori on oncogenesis and progression of pancreatic cancer. Method The current literatures on the relationship between the Helicobacterpylori and the pancreatic cancer were collected and reviewed. Results The Helicobacter pylori infection might play a role in the development of the pancreatic cancer. The infection rate of the Helicobacterpylori in the patients with pancreatic cancer is higher than that of the healthy controls; furthermore, in the patients with Helicobacter pylori antibody positive, the infection rate of the Helicobacter pylori in the cytotoxin-associated gene A-negative strains of Helicobacter pylori is significantly higher than that of the healthy controls. Conclusions Helicobacter pylori infection is related to occurrence and development of pancreatic cancer. Specific mechanism is still not clarified and further research is need to study.

关 键 词：幽门螺杆菌 胰腺癌 发病机制 慢性胰腺炎 

分 类 号：R735.9[医药卫生—肿瘤]