miR-146a单核苷酸多态性与肝细胞癌遗传易感性的meta分析  

fAssociation between miR-146a single nucleotide polymorphism and genetic susceptibility to bepatocellularcarcinoma： a meta-analysis

作　　者：张立洪 张传永[2] 戴新征[2] 张杰[2] 张峰[2] 

机构地区：[1]扬州大学附属泰兴市人民医院普外科,225400 [2]南京医科大学第一附属医院肝脏移植中心,210029

出　　处：《中华肝脏病杂志》2017年第10期749-754,共6页Chinese Journal of Hepatology

基　　金：国家自然科学基金（81273262）

摘　　要：目的综合评估miR-146a单核苷酸多态性与肝细胞癌（HCC）遗传易感性的关系。方法计算机检索Pubmed、WebofScience、Cochrane、万方医学数据库以及谷歌学术等。查找有关miR-146a单核苷酸多态性与HCC遗传易感性的病例对照研究，检索截止日期为2016年10月以电子论文形式发表的中文和英文文献。对文献异质性评价采用Q统计量法。结果最终纳入文献18篇，共有病例5610例和对照7531例用于meta分析。miR-146a单核昔酸多态性与HCC易感性之间无明显关联。5个遗传模型的结果如下：等位基因模型C与G[OR（比值比）=0．96，95％CI（可信区间）为0．88-1．06，P=0．440]；杂合子模型CG与GG（OR=0．99，95％CI为0．90～1．10，P=0．898）;纯合子模型CC与GG（OR=0．91，95％CI为0．75-1．10，P=0．314）；显性模型CC＋CG与GG（OR=0．97，95％CI为0．79～1．19，P=0．759）；隐性模型CG＋GG与CC（OR=1．05，95％甜为0．94-1．18，P=0．405）。对种族、对照人群来源以及哈迪-温伯格平衡分别在5种遗传模型中进行亚组分析，只在隐性模型CG＋GG与CC对照人群来源为基于群体的研究亚组中发现miR-146a单核苷酸多态性增加HCC易感性（OR=1．20，95％甜为1．02-1．40，P=0．024），其余模型的各亚组分析未显示miR-146a rs2910164多态性与HCC易感性有关联。对HBV感染进行分层分析，结果显示miR-146ars2910164多态性增加了HBV阳性HCC发生的风险（OR=1．26，95％CI为1．10-1．49，P=0．001）。结论miR-146a的rs2910164多态性与HCC发生风险之间无明显关联，但可能增加HBV阳性HCC发生的风险。Objective To investigate the association between miR-146a single nucleotide polymorphism and genetic susceptibility to hepatocellular carcinoma （HCC）. Methods PubMed, Web of Science, Cochrane Library, Wanfang Data, and Google Scholar were searched for case-control studies on the association between miR-146a single nucleotide polymorphism and genetic susceptibility to HCC published up to October, 2016 in Chinese or English. The Q-statistics test was used to evaluate the heterogeneity of these articles. Results A total of 18 articles with 5 610 cases and 7 531 controls were included for the meta-aualysis. There was no significant association between miR-146a single nucleotide polymorphism and genetic susceptibility to HCC. The odds ratio （OR）, 95% confidence interval （95% CI）, and P values for the five genetic models were as follows： the allelemodel C/G （OR = 0.99, 95% CI0.88-1.06,P = 0.440）; the heterozygous model CG/GG （OR = 0.99, 95% CI0.90- 1.10, P = 0.898）; the homozygous model CC/GG （OR = 0.91, 95% CI 0.75-1.10, P = 0.314）; the dominant model CC＋CG/GG （OR = 0.97, 95% CI 0.79-1.19, P = 0.759）; the recessive model CG＋GG/CC （OR = 1.05, 95% CI 0.94-1.18, P = 0.405）. A subgroup analysis of race, source of control population, and Hardy-Weinberg equilibrium were performed in these five genetic models, and miR-146a single nucleotide polymorphism increased the susceptibility to HCC only in the control population-based subgroups of the recessive model CG＋GG/CC （OR = 1.20, 95% CI 1.02-1.40, P = 0.024）. There was no association between miR-146a rs2910164 polymorphism and susceptibility to HCC in all the other subgroups. A stratified analysis of HBV infection revealed that miR-146a rs2910164 polymorphism increased the risk of HBV-positive HCC （OR = 1.26, 95% CI 1.10-1.49, P = 0.001）. Conclusion There is no significant association between miR-146a rs2910164 polymorphism and the risk of HCC, but miR- 146a rs2910164 polymorphism may increase the risk of HBV-positive HCC.

关 键 词：癌  肝细胞 多态性 单核昔酸 MIR-146A META分析 

分 类 号：R735.7[医药卫生—肿瘤]