广东汉族人群JAK2 rs7849191位点单核甘酸多态性与2型糖尿病遗传易感性研究  

Relationship between JAK2 rs7849191 single nucleotide polymorphism and genetic susceptibility in Guangdong Han population with type 2 diabetes mellitus

作　　者：于海兵 何小艺 梁碧玉 巫舢 孔丹莉 潘海燕 丁元林 

机构地区：[1]广东医科大学公共卫生学院,广东东莞523808

出　　处：《广东医科大学学报》2017年第4期329-332,共4页Journal of Guangdong Medical University

基　　金：国家自然科学面上基金(No.81273166);东莞市国际科技合作(含港澳台)项目(No.20135081520017);广东高校省级重点平台和重大科研项目(No.2015KTSCX048);东莞市医疗卫生科技计划一般项目(No.201605101290)

摘　　要：目的了解JAK2 rs7849191位点单核苷酸多态性(SNP)与2型糖尿病遗传易感性关系。方法采用SNPscan TM分型技术检测广东地区汉族人群中1 092例2型糖尿病患者和1 092名正常对照JAK2 rs7849191位点基因型,比较两组中基因型及等位基因频率分布。结果糖尿病患者和正常对照中JAK2 rs7849191位点的等位基因频率和基因型频率分布差异无统计学意义(P>0.05)。结论广东地区汉族人群中2型糖尿病患者遗传易感性可能与JAK2 rs7849191位点SNP无关。Objective To investigate the relationship between JAK2 rs7849191 single nucleotide polymorphisms （SNP） and genetic susceptibility in type 2 diabetes mellitus （T2DM）. Methods The genotypes of JAK2 rs7849191 locus in 1 092 patients with T2DM and 1 092 normal controls in Guangdong Han population were detected by SNPscanTM typing technique. Genotype and allele frequencies were analyzed in both groups. Results There were no significant differences in allele and genotype frequencies of JAK2 rs7849191 locus between T2DM and control groups （P〉0.05）. Conclusion Genetic susceptibi- lity to type 2 diabetes mellitus may be unrelated to JAK2 rs7849191 SNP in Guangdong Han population.

关 键 词：2型糖尿病 单核苷酸多态性 JAK2基因 

分 类 号：R587.1[医药卫生—内分泌]