高危型人乳头瘤状病毒感染与湖北十堰食管鳞癌发生的关系研究  

A study about the relationship between high-risk human papillomavirus infection and the incidence of esophageal squamous cell carcinoma in Shiyan,Hubei

作　　者：秦豫培[1] 刘鹏[1] 邹灿[1] 杨丽[1] 孙珊 胡阳黔[1] 

机构地区：[1]湖北医药学院附属东风总医院消化内科,湖北十堰442000

出　　处：《现代肿瘤医学》2017年第22期3610-3612,共3页Journal of Modern Oncology

摘　　要：目的:检测高危型人乳头瘤病毒(human papillomavirus,HPV)在十堰地区食管鳞癌(esophageal squamous cell carcinoma,ESCC)组织中的感染率,分析其相关性。方法:收集十堰地区87例食管鳞癌组织和50例对照组食管组织,实时荧光定量PCR法检测组织中HPV16感染率。结果:食管鳞癌组织和对照组食管组织中HPV16的检出率分别为57.5%和36.0%,食管鳞癌组织中HPV16感染率显著高于对照组(P=0.016<0.05)。分析食管鳞癌患者年龄、性别、病理分级、大体分型、浸润深度、淋巴结侵犯以及TNM分期与HPV16感染的关系,差异均无统计学意义。HPV16感染与食管鳞癌患者临床特征未见显著相关性。结论:HPV16感染可能是十堰地区食管鳞癌发生的因素之一,针对高危型HPV感染的防治对于该地区食管鳞癌的发生具有重要意义。Objective：To detect the infection rate of high-risk human papillomavirus （HPV） in the tissues of esophageal squamous cell carcinoma （ESCC） in Shiyan and analyse their relationship.Methods：To collect 87 ESCC tissues and 50 controls esophageal tissues,and detect the HPV16 infection rate in tissues by real-time PCR.Results：The infection of HPV16 in ESCC tissues and controls were 57.5% and 36.0%,respectively.The HPV16 infection rate in ESCC tissues was significantly higher than in controls （P=0.016〈0.05）.There were no significant differences between the HPV16 infection rate and the age,gender,tumor differentiation,general classification,infiltration depth,lymph node status and TNM staging.No significant difference could be seen between the HPV16 infection and clinical characteristics of ESCC patients.Conclusion：HPV16 infection may be one of the pathogenic factors of ESCC in Shiyan,which indicates the infection of high-risk HPV could be helpful for the prevention of ESCC in Shiyan.

关 键 词：食管鳞癌 人乳头瘤病毒 PCR 

分 类 号：R735.1[医药卫生—肿瘤]