三氧化二砷对肝癌细胞侵袭和转移能力的影响  

Effect of arsenic trioxide on invasion and metastasis in hepatocellular carcinoma

作　　者：刘桃桃 张士德[1] 

机构地区：[1]哈尔滨医科大学附属第二医院放射科,黑龙江哈尔滨150086

出　　处：《现代肿瘤医学》2017年第22期3708-3712,共5页Journal of Modern Oncology

基　　金：黑龙江省自然科学基金项目(编号:D201212)

摘　　要：原发性肝癌患者首选手术切除根治疗法,但由于肝癌具有早期侵袭和转移的生物学特性,使大部分肝癌发现时已为中晚期,失去手术机会,死亡率和复发率高。三氧化二砷可以通过抑制肿瘤细胞黏附作用、抑制上皮间充质转化过程、抑制CD44、MMPs、VEGF、B7-H3、B7-H4、MIF、CD147等表达、诱导肿瘤干细胞分化等抑制肝癌细胞侵袭和转移能力,单药或联合应用于临床治疗,抑制肿瘤转移复发,延长患者生存时间并提高生存质量,将可能成为有应用前景的抗癌药物选择。Primary hepatocellular carcinoma （HCC） is one of the most common types of cancer and it is responsible for significant mortality and recurrence rate worldwide.Surgical resection is considered to be the primary therapeutic approach for the management of HCC,whereas the majority of HCC are diagnosed at intermediate or advanced stages due to the invasion and metastasis of HCC in early phase.Arsenic trioxide could inhibit the invasion and metastasis of HCC via inhibits adhesive action and epithelial-mesenchymal transition,decreases the expression of CD44,MMPs,VEGF,B7-H3,B7-H4,MIF,CD147,and induces cancer stem cells differentiation.Arsenic trioxide,alone or combined with other treatment methods,could inhibit metastasis and recurrance,prolong the survival time and improve life quality,then it may be a promising medicine for curing cancer in the future.

关 键 词：肝癌 三氧化二砷 侵袭 转移 

分 类 号：R735.7[医药卫生—肿瘤]