CYP1A1基因多态性对多西他赛联合卡培他滨治疗转移性乳腺癌疗效的影响  

Effect of CYP1A1 polymorphism on the clinical efficacy of docetaxel combined with capecitabine in the treatment of metastatic breast cancer

作　　者：李林[1] 熊有毅 王芳[1] 郭广成[1] 秦威[1] 朱明智[1] 王楠[1] 段馨[1] 陈卓[1] 米海龙[1] 王燕燕[1] 谷元廷[1] 李靖若[1] 

机构地区：[1]郑州大学第一附属医院乳腺外科,450052

出　　处：《中华实验外科杂志》2017年第10期1760-1762,共3页Chinese Journal of Experimental Surgery

摘　　要：目的在经多西他赛联合卡培他滨治疗的复发转移性乳腺癌（MBC）患者中，探讨细胞色素P450（CYP450）酶基因的单核苷酸多态性（SNP）和患者治疗疗效个体化差异的关系。方法研究入组69例接受多西他赛联合卡培他滨方案治疗的MBC患者，治疗前通过飞行时间质谱和直接测序法对CYP450基因上中国人群中最小等位基因频率（MAF）≥10%的79个多态性位点进行基因分型，并分析这79个SNP位点和多西他赛联合卡培他滨治疗的反应率以及预后的相关性。结果79个SNP位点中只有CYP1A1的rs1048943（Ile462Val）位点与无进展生存期（PFS）显著相关（P＝0.000），其他SNP位点与治疗反应率以及总生存期（OS）无明显相关。进一步分析，将rs1048943（Ile462Val）位点纳入COX风险比例模型校正后，表明该位点是影响PFS独立的预测指标（P＝0.004）。结论检测CYP1A1的多态性位点rs1048943（Ile462Val）对接受多西他赛联合卡培他滨方案方案治疗的MBC患者有助于评估预测预后。ObjectiveIn recurrent metastatic breast cancer （MBC） patients treated with docetaxel combined with capecitabine, we aimed to investigate the correlation between single nucleotide polymorphisms （SNPs） of cytochrome 450 （CYP450） gene and individual differences in clinical outcomes. MethodsSixty-nine MBC patients who were treated with docetaxel plus capecitabine were included in this study. And 79 SNPs in CYP450 gene, whose minorallele frequency （MAF） was 〉10% in the Chinese population were genotyped by TOF mass spectrometry and direct sequencing. The associations between these 79 SNPs and clinical outcomes were further analyzed.ResultsOnly the CYP1A1 rs1048943 （Ile462Val） among 79 SNPs was signiflcantly associated with progression-free survival （PFS, P=0.000）. There was no significant correlation between other SNPs and treatment response rate and overall survival （OS）. The rs1048943 （Ile462Val） site was included in the COX risk ratio model for further analysis. After adjustment, we conflrmed that it was an independent predictor of PFS （P=0.004）. Conclusion CYP1A1 rs1048943 polymorphism is probably an independent prognostic marker for survival outcome in MBC patients treated with docetaxel plus capecitabine chemotherapy.

关 键 词：乳腺癌 细胞色素P450 多态性 

分 类 号：R737.9[医药卫生—肿瘤]