DNA Methylation and Birth Weight: a Genome-wide Analysis  

作　　者：MAO Li Li XIAO Xin Hua ZHANG Qian ZHENG Jia LI Wen Hui YU Miao ZHANG Hua Bing PING Fan XU Jian Ping WANG Xiao Jing 

机构地区：[1]Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Diabetes Research Center of Chinese Academy of Medical Sciences & Peking Union Medical College [2]Department of Endocrinology, Civil Aviation General Hospital

出　　处：《Biomedical and Environmental Sciences》2017年第9期667-670,共4页生物医学与环境科学（英文版）

基　　金：supported by the National Natural Science Foundation of China(NSFC),project number is 81170736 and 81570715

摘　　要：The study illustrate the inner correlation between global DNA methylation variation and different birth weights. Infant birth weight was used to identify cases and controls. Cord blood and placentas were collected. We performed DNA methylation profiling of bisulphite‐converted DNA. We have identified many differentially methylated Cp G sites in experimental groups; these sites involved in hundreds of signalings. Among these, more than ten pathways were referred to the glucose and lipid metabolism. Methylation changes in the insulin‐signaling pathway（ISP）, adipocytokine signaling pathway（ASP） and MAPK signaling pathway are involved in the fetal programming of diabetes.The study illustrate the inner correlation between global DNA methylation variation and different birth weights. Infant birth weight was used to identify cases and controls. Cord blood and placentas were collected. We performed DNA methylation profiling of bisulphite‐converted DNA. We have identified many differentially methylated Cp G sites in experimental groups; these sites involved in hundreds of signalings. Among these, more than ten pathways were referred to the glucose and lipid metabolism. Methylation changes in the insulin‐signaling pathway（ISP）, adipocytokine signaling pathway（ASP） and MAPK signaling pathway are involved in the fetal programming of diabetes.

关 键 词：DNA Methylation and Birth Weight ASP LBW DNAMETHYLATION 

分 类 号：R722.1[医药卫生—儿科]