MRI对帕金森病患者DBS术前丘脑底核的直视化定位扫描  

A study of preoperative MRI scan sequences for stereotactic visualization of subthalamic nucleus in deep-brain stimulation procedures for patients with Parkinson's disease

作　　者：罗晓[1] 何品[1] 蔡晓东[2] 张豆豆[2] 吴清平[3] 姚薇薇[1] 雷益[1] 夏军[1] 

机构地区：[1]深圳市第二人民医院影像科,广东深圳518035 [2]深圳市第二人民医院功能神经外科,广东深圳518035 [3]深圳市第二人民医院统计室,广东深圳518035

出　　处：《广东医学》2017年第19期2946-2949,共4页Guangdong Medical Journal

基　　金：广东省科技计划项目(编号:2014A020212044;2014A020212047);深圳市卫生计生系统科研项目(编号:201401019)

摘　　要：目的探讨并对比研究丘脑底核(STN)的MRI最佳直视化扫描序列。方法对10例正常人及10例帕金森病(PD)患者深部脑电刺激术(DBS)前进行扫描,与以往常规序列对比,半定量分析各种扫描序列对于STN显示的情况,术后复查并确认患者微电极记录(MER)电极探针位置。结果 T2~*flash2D和T2-SPACE,SWI imaging序列半定量评分高于常用的T1-mprage、T2-TSE序列及FLAIR序列,并与患者术中MER确定的电极探针位置有较高的一致性。结论使用T2~*flash2D、T2-SPACE和SWI imaging序列可以准确预定靶点位置,能够提高定位精确度,避免并发症,提高手术效率。Objective To investigate and comparative the best MRI sequences to visualize the subthalamic nucle- us （STN） as the operation target. Methods Ten patients with PD were included. Ten healthy subjects were taken as control group. Sequences that we chose were compared with the conventional sequences. Different sequences were analyzed semi - quantitatively when applied to visualize the STN before DBS procedures. The intra - operative microelectrode recording （MER） electrode probe positioning was reviewed and confirmed after operation. Results The T2 ＊ flash 2D, T2 - SPACE and SWI sequences were higher than conventional T1 - mprage, T2 - TSE and FLAIR in semi - quantitative scores, with higher consistency with the intra - operative MER confirmed electrode probe positioning. Conclusion T2 ＊ flash 2D, T2 -SPACE and SWI sequences can provide accurate targeting for STN deep brain stimulation, and can improve the positioning accuracy, avoid complications and improve the operation efficiency.

关 键 词：丘脑底核 帕金森病 磁共振成像 

分 类 号：R742.5[医药卫生—神经病学与精神病学]