酒精戒断综合征致横纹肌溶解的临床分析  

Clinical analysis of rhabdomyolysis syndrome caused by alcohol withdrawal syndrome

作　　者：钟强[1] 龚丽 何虹茜 Zhong Qiang Gong Li He Hongqian(Department of Gastroenterology, the First People＇ s Hospital of Zigong City, Sichuan Zigong 643000, Chin)

机构地区：[1]四川省自贡市第一人民医院消化科,643000 [2]四川省凉山州美姑县人民医院消化科

出　　处：《中国医师进修杂志》2017年第9期800-802,共3页Chinese Journal of Postgraduates of Medicine

摘　　要：目的 分析酒精戒断综合征（AWS）致横纹肌溶解（RM）的临床特点.方法 回顾性分析7例AWS致RM患者的临床资料.结果 7例患者均为男性;年龄38～63（51.3±9.8）岁.7例均有明显肌痛和乏力,4例有肢体肿胀,3例有上腹痛.7例肌酸激酶和肌红蛋白均明显升高.1例出现急性肾衰竭.7例患者经大量补液等治疗后均好转出院.结论 以全身性戒断抽搐和癫痫持续状态发作的AWS患者因肌肉长时间剧烈收缩,肌细胞受到破坏可引起RM.临床接诊AWS患者时应监测肌酸激酶、肌红蛋白、肾功能及肝功能的变化,如发生RM应早期补液治疗.Objective To analyze the characteristics of rhabdomyolysis （RM） caused by alcohol withdrawal syndrome （AWS）. Methods The clinical data of 7 patients with RM induced by AWS were analyzed retrospectively. Results All 7 patients were male;the age was 38-63 （51.3 ± 9.8） years. All of the 7 patients showed obvious myalgia and fatigue, of whom 4 patients had limb swelling, and 3 patients had epigastric pain. Creatine kinase and myoglobin levels of 7 cases were significantly increased. One case had acute renal failure. Seven patients were improved after treatment with a large amount of fluid infusion. Conclusions For patients with AWS who have generalized withdrawal seizures and epileptic seizures, muscle cells can be damaged due to prolonged muscle contraction, which can cause RM. Changes of myoglobin, creatine kinase, renal function and liver function in patients with AWS should be monitored at clinical admissions. If RM occurs, the patients should be given early fluid therapy.

关 键 词：物质戒断综合征 横纹肌溶解 肌酸激酶 肌红蛋白 回顾性研究 

分 类 号：R749.62[医药卫生—神经病学与精神病学]