免疫组化标记Stathmin-1与p16在宫颈上皮内瘤变分级中的作用  

Immunohistochemical labeling of Stathmin-1 and p16 in grading of cervical intraepithelial neoplasia

作　　者：姚晨[1] 丁岚[1] 杨永国[1] 梅霞[1] YAO Chen DING Lan YANG Yong-guo MEI Xia(Department of Patholog Jiangdu people＇s Hospital of Yangzhou, Jiangsu Yangzhou 225200,China)

机构地区：[1]扬州市江都人民医院病理科,江苏扬州225200

出　　处：《临床医药文献电子杂志》2017年第47期9111-9112,共2页Electronic Journal of Clinical Medical Literature

摘　　要：目的分析Stathmin-1与p16在宫颈上皮内瘤变分级中的作用,为临床治疗提供帮助。方法采用免疫组织化学技术检测Stathmin-1与p16在正常宫颈组织及上皮内瘤变(CIN)中的表达,使CIN分级更加精确。结果 Stathmin-1在正常宫颈组织、CINI、CINII、CINIII中的阳性表达率分别为6.7%、25%、42.2%、91.7%。P16在正常宫颈组织、CINI、CINII、CINIII中的阳性表达率分别为13.3%、70%、95.6%、100%。两者表达结果表明Stathmin-1在宫颈的鳞状上皮低度病变分类鉴别中,比p16具有更高的特异性。结论Stathmin-1在CINIII中呈过度表达,而在低级别病变中不表达或部分表达,有助于鉴别高级别、低级别CIN和良性反应性改变,进而为临床诊治采取哪种治疗手段提供帮助。Objective To analyze the role of Stathmin-1 and p16 in grading of cervical intraepithelial neoplasia, and to provide information for clinical treatment. Methods Immunohistochemistry was used to detect the expression of Stathmin-1 and p16 in normal cervical tissues and intraepithelial neoplasia （CIN）, which made CIN grading more accurate. Results The positive expression rates of Stathmin-1 in normal cervical tissues, CINI, CINII and CINIII were 6.7%, 25%, 42.2% and 91.7%, respectively. The positive expression rates of p16 in normal cervical tissues, CINⅠ, CINⅡ and CINⅢ were 13.3%, 70%, 100% and 93.8%, respectively. The results indicated that Stathmin-1 is more specific than p16 in classification and identification of squamous lesions of squamous epithelium of the cervix. Conclusion Stathmin-1 was overexpressed in CINIII, and in the low grade lesions did not express or partial expression, is helpful in the differential diagnosis of high level and low level of CIN and benign changes, and for clinical diagnosis and treatment of what kind of treatment to help.

关 键 词：宫颈上皮内瘤变 Stathmin-1 P16 

分 类 号：R737.33[医药卫生—肿瘤]