无创DNA产前检测在21-三体综合征高危孕妇中的应用探讨  

Discussion of application prenatal detection of noninvasive DNA in the trisomy-syndrome high-risk pregnant women

作　　者：刘伟[1] 陈寸 石秀凤[1] 吴俏坪 邢维珍 

机构地区：[1]海南省三亚市妇幼保健院,海南三亚572000

出　　处：《中国优生与遗传杂志》2017年第9期40-41,17,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨无创DNA产前检测在21-三体综合征高危孕妇中的应用价值,进而为现有的临床研究数据进行补充。方法回顾性分析2014年05月至2017年05月在海南省三亚市妇幼保健院经NT+PAPPA+h CGβ联合筛查提示21-三体综合征高危并行无创DNA产前检测的22例孕妇临床资料。其中,对无创DNA产前检测仍提示高风险者给予介入性产前诊断。以此评价无创DNA产前检测的准确性和可靠性。结果在22例经NT+PAPPA+h CGβ联合筛查提示21-三体综合征的高危孕妇中,无创DNA产前检测检出20例,介入性产前诊断19例,其无创DNA产前检测的准确率高达95%。结论无创DNA产前检测在21-三体综合征高危孕妇中的临床应用价值较准确和可靠,为目前21-三体综合征高危孕妇筛查的首选方法。Objective：Discussion of application prenatal detection of noninvasive DNA in the trisomy-syndrome high-risk pregnant women so that for the existing clinical study data made a supplementary. Methods：Retrospectively during May 2014 to May 2017 in Maternity and Child Health Hospital of Sanya passed through NT＋PAPPA＋h CGβ unite screening hint that trisomy-syndrome high-risk pregnant women and carried out prenatal detection of noninvasive DNA on 22 cases pregnant women of clinical data. Among them,for prenatal detection of noninvasive DNA still hint high-risk who was given interventional prenatal diagnosis. On this account,To evaluate the veracity and reliability of prenatal detection of noninvasive DNA. Results：In 22 cases by NT＋PAPPA＋h CGβ unite screening hint that trisomy-syndrome high-risk pregnant women,who 20 cases were detected by prenatal detection of noninvasive DNA. But by the interventional prenatal diagnosis were only 19 cases. Therefore,the prenatal detection of noninvasive DNA detection accuracy up to 95%. Conclusion：Prenatal detection of noninvasive DNA in the trisomy-syndrome high-risk pregnant women of the clinical application value are accurate and reliable,which is as a trisomy-syndrome high-risk pregnant women screening preferred method.

关 键 词：无创DNA产前检测 21-三体综合征 唐氏综合征 应用探讨 

分 类 号：R714.5[医药卫生—妇产科学]