CEA联合CA19-9检查在胆胰腺癌诊断中的价值  

Value of CEA combined with CA19-9 examination in the diagnosis of biliary and pancreatic cancers

作　　者：周长升[1] 芶欣[1] 黄建钊[1] 相一 

机构地区：[1]贵州省人民医院肝胆外科,贵州贵阳550002

出　　处：《肝胆胰外科杂志》2017年第5期385-388,共4页Journal of Hepatopancreatobiliary Surgery

摘　　要：目的探讨CEA联合CA19-9检查在胆胰腺癌诊断中的价值。方法收集2012年8月至2015年7月贵州省人民医院肝胆外科收治的B超、CT、MRI等影像学检查提示胆道梗阻和胆道、胰腺占位,行CEA、CA19-9检查的患者800例,结合病理结果回顾性分析CEA联合CA19-9检查对胆胰腺癌诊断的准确率。结果单独CEA阳性(>3.40μg/L)时,胆胰腺癌的诊断准确率为27.78%;单独CA19-9阳性(>39.00 U/mL)时,胆胰腺癌的诊断准确率为35.43%;CEA和CA19-9均阳性时,胆胰腺癌的诊断准确率为85.71%;当提高阳性设定值CEA>3.50μg/L,CA19-9>200.00 U/mL时,胆胰腺癌的诊断准确率为95.42%。CEA和CA19-9同时阳性且持续升高时,依据之前的两组阳性设定值,胆胰腺癌的诊断准确率分别为95.91%和98.41%。结论 CEA联合CA19-9检查能够显著提高胆胰腺癌诊断的准确率,尤其当CEA>3.50μg/L同时CA19-9>200.00 U/mL,而且二者持续升高时。objective To explore the value carcinoembryonic antigen（CEA） combined with cancer antigen 19-9（CA19-9） examination in the diagnosis of biliary and pancreatic cancers.Methods The study included 800 patients who diagnosed as benign（malignant） biliary obstruction or（and） space-occupying lesions in the biliary tract or pancreas by ultrasound,computed tomography（CT） and magnetic resonance imaging（MRI）,and then underwent CEA and CA19-9 examinations in Guizhou Provincial People＇s Hospital between Aug.2012 and Jul.2015.The diagnosis accuracy of CEA and CA19-9 combined examination on the biliary and pancreatic cancers was retrospectively evaluated by pathological results.Results The diagnosis accuracy of biliary and pancreatic cancers was 27.78% with only CEA positive（3.40 μg/L）,and 35.43% with only CA19-9 positive（39.00 U/mL）,the combined diagnosis accuracy was 85.71% when the positive value set higher CEA（3.50 μg/L and CA19-9200.00 U/mL）,the combined diagnosis accuracy was 95.42%.When the levels of CEA and CA19-9 were continuously increasing,the diagnostic accuracy rate of biliary and pancreatic cancers significantly increased,according to above two positive value sets,were 95.91% and 98.41%,respectively.Conclusion The combined examination CEA and CA19-9 can significantly increase the diagnosis accuracy rate of biliary and pancreatic cancers,especially for the patients with both CEA3.50 μg/L and CA19-9200.00 U/mL and CEA and CA19-9 increasing continuously.

关 键 词：癌胚抗原(CEA) 糖链抗原19-9(CA19-9) 联合检查 胆胰腺癌 诊断准确率 

分 类 号：R735[医药卫生—肿瘤]