IL-6、IL-10联合BISAP评分在重症急性胰腺炎预后评估中的作用研究  

Research of IL-6 and IL-10 Combined with BISAP Score in Evaluation of Prognosis in Patients with Severe Acute Pancreatitis

作　　者：卓越 邱小松 薛婷 李丽 金鑫 

机构地区：[1]徐州医科大学附属医院急救中心,江苏徐州221002

出　　处：《现代生物医学进展》2017年第29期5708-5711,共4页Progress in Modern Biomedicine

摘　　要：目的:探讨白细胞介素-6(IL-6)、白细胞介素-10(IL-10)联合急性胰腺炎严重程度床边指数(BISAP)评分在重症急性胰腺炎(SAP)预后评估中的作用。方法:回顾性分析2013年5月至2016年5月我院收治的131例SAP患者的临床病历资料,患者入院后24h内采用酶联免疫吸附法(ELISA)检测血清IL-6和IL-10水平,并进行BISAP评分,同时以接近IL-6、IL-10、BISAP评分中位数的自然值为界值,比较不同预后(死亡、感染、多器官功能障碍综合征(MODS)、局部并发症)的发生率。结果:死亡、MODS、感染患者血清IL-6水平、BISAP评分高于局部并发症患者,血清IL-10水平低于局部并发症患者(P<0.05);死亡、MODS患者血清IL-6水平、BISAP评分高于感染患者,血清IL-10水平低于感染患者(P<0.05);死亡患者血清IL-6水平、BISAP评分高于MODS患者,血清IL-10水平低于MODS患者,差异有统计学意义(P<0.05)。IL-6≥65μg/L、IL-10<40μg/L、BISAP评分≥3分患者死亡、MODS、感染发生率更高,差异有统计学意义(P<0.05)。经Pearson积矩相关分析,IL-6、BISAP评分之间呈正相关关系(r=0.617,P<0.05),IL-6、BISAP评分与IL-10之间呈负相关关系(r=-0.572、-0.611,P<0.05)。结论:IL-6、IL-10、BISAP评分是评估SAP预后的重要指标,IL-6水平、BISAP评分越高、IL-10水平越低,患者预后越差,联合应用的预测价值高,临床可作为参考。Objective： To explore the effect of interleukin-6（IL-6）, interleukin-10（L-10） combined with acute pancreatitis severity index （BISAP） score in the evaluation of prognosis in patients with severe acute pancreatitis （SAP）. Methods： The clinical data of 131 patients with SAP, who were admitted to Affiliated Hospital of Xuzhou Medical University from May 2013 to May 2016, were retrospec- tively analyzed. The levels of serum IL-6 and IL-10 were detected by the enzyme-linked immunosorbent assay （ELISA） within 24 h after admission, and the BISAP score was measured. Taking the natural value of the median of IL-6, IL-10 and BISAP score as the boundary value, the occurrence rotes of different prognosis （death, infection, multiple organ dysfunction syndrome （MODS） and local complications） were compared at the same time. Results： The levels of serum IL-6, BISAP score of the patients with death, MODS, and infection were higher than those of the patients with local complications, and the levels of serum IL- 10 was lower than those of the patients with local complications （P〈0.05）. The levels of serum IL-6, BISAP score of the patients with death, MODS were higher than those of the patients with infection, and the levels of serum IL-10 was lower than those of the patients with infection, the difference was statistically significant （P〈0.05）. The incidence of death, MODS, infection in patients with IL-6≥65μg/L, IL-10〈40μg/L, BISAPscore≥3 was much higher, the difference was statistically significant （P〈0.05）. By the Pearson product moment correlation analysis, there was a positive correlation be- tween IL-6 and BISAP score （1=0.617, P〈0.05）, while there was a negative correlation between IL-6 and BISAP score and IL-10 （1=-0. 572, -0.611, P〈0.05）. Conclusion： IL-6, IL-10 and BISAP score are the important indexes to evaluate the prognosis of SAP, The higher the IL-6 level, the higher the BISAP score, the lower the level oflL-10, the worse the prognosis. The pr

关 键 词：重症急性胰腺炎 白细胞介素-6 白细胞介素-10 急性胰腺炎严重程度床边指数 预后 

分 类 号：R576[医药卫生—消化系统]