B7-H4在胰腺癌中的表达及与临床病理及预后的相关性分析  

Expression of B7-H4 in pancreatic cancer and the relevant research with clinical pathology and prognosis

作　　者：王琪[1] 沈凌炜[1] 钱韵[1] 

机构地区：[1]浙江大学医学院附属第二医院

出　　处：《实验与检验医学》2017年第5期642-645,共4页Experimental and Laboratory Medicine

基　　金：浙江省自然科学基金;LQ16H160005

摘　　要：目的研究B7-H4异常表达于胰腺癌组织,其表达水平与胰腺癌预后的相关性。方法收集浙江大学医学院附属第二医院2011年1月至2014年12月间胰腺癌切除手术取得的胰腺癌组织(188例),以及非肿瘤患者胰腺组织(25例)。通过免疫组织化学染色方法检测B7-H4在上述组织中的表达。结果胰腺癌组织中B7-H4表达阳性率为100%,明显高于非肿瘤患者胰腺组织(68%),且胰腺癌组织中B7-H4的表达水平明显高于对照组。同时,胰腺癌组织中B7-H4的表达水平与TNM分级、远端转移及分化显著相关。多因素生存分析显示,B7-H4表达水平、远端转移以及化疗为独立的胰腺癌预后指标。结论 B7-H4在胰腺癌组织中异常表达,为独立的胰腺癌不良预后指标,有望成为胰腺癌治疗的免疫靶点。Objective To study B7-H4 abnormally expressed in pancreatic cancer tissues,and to evaluate the correlation between B7-H4 and the prognosis of pancreatic cancer. Methods Pancreatic cancer patients（n=188） and healthy controls（n=25）were collected from the Second Affiliated Hospital of Zhejiang University school of medical from January 2011 to December 2014.Immunohistochemical staining was used to detect the expression of B7-H4. Results The positive rate of B7-H4 expression in pancreatic cancer tissues was 100%,higher than that in normal pancreatic tissue samples（68%）. And the expression level of B7-H4 in pancreatic cancer were obviously higher than control group. Meanwhile,the expression of B7-H4 in pancreatic cancer was significantly correlated with tumornodemetastasis（TNM） stage,distant metastasis and differentiation. Multivariate survival analysis showed that the expression level of B7-H4,distant metastasis,and chemotherapy were independent prognostic index of pancreatic cancer. Conclusion Abnormal expression of B7-H4 in pancreatic cancer is an independent prognostic marker of pancreatic cancer and is expected to be an immune target for the treatment of pancreatic cancer.

关 键 词：B7-H4 胰腺癌 预后 生物标志 免疫组化 

分 类 号：R735.9[医药卫生—肿瘤] R446.8[医药卫生—临床医学]