槲皮素逆转肿瘤多药耐药机制的研究进展  

Research Progress on Quercetin in Reversing Tumor Multidrug Resistance

作　　者：党树伟 李国东[1] 刘明[1] 

机构地区：[1]哈尔滨医科大学附属第四医院,黑龙江哈尔滨150001

出　　处：《中国肿瘤》2017年第10期802-807,共6页China Cancer

基　　金：国家自然科学基金(81372612);国家自然科学青年基金(81302059);黑龙江省留学归国科学基金(LC2013C35)

摘　　要：恶性肿瘤已成为当今威胁人类健康的重大疾病。目前,肿瘤的治疗主要是以手术为主的综合治疗,其中化疗药物的应用可明显抑制肿瘤生长、改善患者预后,但肿瘤的多药耐药严重阻碍了其治疗效果。槲皮素是广泛存在于植物中、具有生物活性的黄酮类化合物,具有抗肿瘤等多种药理学作用。目前,槲皮素逆转肿瘤多药耐药作用已引起广泛关注。研究发现,其可通过抑制多种耐药相关蛋白、诱导细胞凋亡、抑制热休克蛋白功能、逆转上皮间质转化等作用,从而逆转肿瘤多药耐药。本文主要综述槲皮素逆转肿瘤多药耐药的分子机制及其临床应用前景,以期为逆转肿瘤多药耐药的基础及临床研究提供新思路。Chemotherapy can significantly inhibit tumor growth and improve the prognosis of patients,but the multidrug resistance may seriously hamper its therapeutic effect. Quercetin is a kind of flavonoid compounds which are widely distributed in plants. Quercetin has a significant anti-tumor effect. At present,the reversing effect of tumor multidrug resistance（MDR） by quercetin has attracted wide attention. It has been found that quercetin can reverse multidrug resistance by inhibiting the expression of MDR-associated proteins,inducing apoptosis,inhibiting the function of heat shock proteins,reversing epithelial mesenchymal transition and so on. In this article,we review the molecular mechanisms of quercetin in reversing multidrug resistance and the prospect of clinical application.

关 键 词：槲皮素 肿瘤 多药耐药 

分 类 号：R73[医药卫生—肿瘤]