Fibulin-7在小鼠下颌第一磨牙发育过程中的时空表达  

Spatiotemporal expression pattern of Fibulin-7 in the development process of murine mandibular first molars

作　　者：欧阳宁鹃 李洪亮[1] 林雨恒[1] 卢陈佩 代杰文[1] 沈国芳[1] 

机构地区：[1]上海交通大学医学院附属第九人民医院.口腔医学院口腔颅颌面科上海市口腔医学重点实验室,上海200011

出　　处：《中国口腔颌面外科杂志》2017年第5期385-387,共3页China Journal of Oral and Maxillofacial Surgery

基　　金：国家自然科学基金(81300842;81570947);上海高校创新团队计划;上海高校高峰高原学科建设项目;上海市青年拔尖人才项目;上海交通大学"晨星学者"奖励计划(C类)

摘　　要：目的:观察Fibulin-7蛋白在小鼠下颌第一磨牙牙胚发育过程中的时空表达特点。方法 :取胚胎15.5 d、出生后第1天、第7天的C57BL/6J小鼠下颌骨标本,应用免疫组织化学方法检测Fibulin-7在下颌第一磨牙牙胚不同发育时期的表达情况。结果:Fibulin-7蛋白在小鼠下颌第一磨牙牙胚自钟状期末期至牙胚发育成熟过程中表达量逐渐增加。结论:Fibulin-7蛋白在牙胚发育的不同阶段均有表达,推测Fibulin-7参与了牙间充质细胞分化为成牙本质细胞、牙髓-牙本质复合体的形成过程。PURPOSE： To investigate the expression patterns of Fibulin-7 in murine tooth germs of mandibular first molars at early developmental stages. METHODS： Mandible samples of C57BL/6J mice of embryonic day 15.5, postnatal day 1 and day 7 were collected. The expressions of Fibulin-7 in murine mandibular first molar germs were detected by immunohistochemistry staining. RESULTS： The expression of Fibulin-7 was detected and gradually increased from late bell stage till maturation of tooth germs in mandibular first molars. CONCLUSIONS： Fibulin-7 was expressed at different stages through the development of tooth germs, indicating their individual functions in the process of mesenchymal cells into odontoblasts and the formation of pulp-dentin complex.

关 键 词：Fibulin-7 小鼠 下颌第一磨牙 时空表达 

分 类 号：R781[医药卫生—口腔医学]