乳腺癌术后放疗联合复方苦参注射液的临床效果观察  

Clinical Effect of Postoperative Radiotherapy Combined with Compound Matrine Injection on the Patients with Breast Cancer

作　　者：魏鹏飞[1] 陈明霞[1] 杨蕴一 张亚密 王军 王会仓 

机构地区：[1]陕西中医药大学第一临床医学院,陕西咸阳712000 [2]西安交通大学第二附属医院放疗科,陕西西安710004 [3]陕西中医药大学附属医院肿瘤科,陕西咸阳712000 [4]陕西中医药大学附属医院药剂科,陕西咸阳712000

出　　处：《现代生物医学进展》2017年第27期5255-5257,5266,共4页Progress in Modern Biomedicine

摘　　要：目的:分析乳腺癌术后放疗联合复方苦参注射液的临床治疗效果。方法:选取2013年3月至2016年3月我院收治的乳腺癌患者83例,本次治疗前均接受保乳及前哨淋巴结活检术以及5周期的辅助化疗。将患者随机分为对照组42例和观察组41例,对照组患者给予单纯术后放疗治疗,观察组给予患者术后放疗联合复方苦参注射液治疗。比较两组患者治疗前后的血清CA125、CA153及CA724,及CD3^+、CD4^+、CD8^+、CD4^+/CD8^+及NK细胞水平,以及不良反应的发生情况。结果:治疗后,两组的血清CA125、CA153及CA724水平均明显降低,且观察组显著低于对照组,差异具有统计学意义(P<0.05)。观察组的CD3^+、CD4^+、CD8^+、CD4^+/CD8^+及NK细胞数较治疗前明显改善,观察组的CD3^+、CD4^+、CD4^+/CD8^+及NK细胞数显著高于对照组,CD8^+显著低于对照组,差异具有统计学意义(P<0.05)。治疗期间,观察组患者的II度以上皮肤反应、骨髓抑制的发生率均显著低于对照组,差异具有统计学意义(P<0.05)。结论:乳腺癌术后放疗联合复方苦参注射液治疗可显著增强机体的细胞免疫功能,且安全性更高。Objective：To investigate the clinical efficacy of postoperative radiotherapy combined with compound matrine injection on the patients with breast cancer.Methods：Eighty-three patients with breast cancer received breast-conserving and sentinel lymph node biopsy before the study who were admitted in our hospital were divided into the control group and observation group.Forty-two patients in control group were treated with postoperative radiotherapy,and forty-one patients in observation group were received postoperative radiotherapy combined with compound matrine injection.The CA125,CA153,CA724,levels of CD3~＋,CD4~＋,CD8~＋,CD4~＋/CD8~＋,NK,and adverse reaction in the two groups were detected and compared.Results：After treatment,the CA125,CA153,and CA724 in both groups were obviously decreased（P0.05）,which were significantly lower in the observation group than those of the control group（P0.05）.CD3~＋,CD4~＋,CD8~＋,CD4~＋/CD8~＋,and NK cell in the observation group showed remarkable improvement（P0.05） compared with those before treatment.And CD3~＋,CD4~＋,CD4~＋/CD8~＋,and NK cell of the observation group were significantly higher than those of the control group,while CD8~＋was much lower（P0.05）.During the treatment period,the incidence of skin reaction over grade II,and myelosuppression in observation group were much lower than those of control group（P0.05）.Conclusion：Postoperative radiotherapy combined with compound matrine injection had good ability in enhancing the cellular immune function and reducing adverse reaction on the patients with breast cancer.

关 键 词：乳腺癌 放疗 复方苦参注射液 肿瘤标志物 免疫功能 

分 类 号：R737.9[医药卫生—肿瘤]