DKK-1和MMP-14在口腔鳞癌中的表达及其意义  

Expressions and Significances of DKK-1 and MMP-14 in the Oral Squamous Cell Carcinoma

作　　者：李祥彬 王鹏[1] 尹学敏 王思思 余少壮 尹晓东[1] 

机构地区：[1]哈尔滨医科大学附属口腔医院口腔颌面外科二科,黑龙江哈尔滨150000

出　　处：《现代生物医学进展》2017年第28期5421-5424,5431,共5页Progress in Modern Biomedicine

基　　金：黑龙江省教育厅科学研究基金项目(11521187)

摘　　要：目的:研究DKK-1蛋白和MMP-14蛋白在口腔鳞状细胞癌组织中的表达和临床意义。方法:选择口腔鳞癌石蜡标本62例作为实验组,25例正常口腔黏膜组织作为对照组。应用免疫组织化学法检测其DKK-1和MMP-14蛋白的表达,并分析二者与口腔鳞癌患者临床病理特征之间的关系及二者表达的相关性。结果:实验组DKK-1的阳性表达率为40.32%,明显低于对照组中(68%),而MMP-14的阳性表达率(72.58%)明显高于对照组(24%)(P<0.05)。DKK-1和MMP-14的表达水平与口腔鳞癌的分期、淋巴结转移及分化程度有显著相关(P<0.05)。口腔鳞癌组织中DKK-1和MMP-14蛋白的表达呈显著负相关(r=-0.600,P<0.05)。结论:口腔鳞状细胞癌组织中DKK-1的表达下调,MMP-14的表达上调,二者可能参与了OSCC的发生和发展过程,并有望用于口腔鳞状细胞癌的病情和预后评估。Objective： To observe and analyze the expressions of DKK-1 and MMP-14 in the oral squamous cell carcinoma （OSCC） and their clinical significances. Methods： 62 cases of paraffin specimens of OSCC was selected as the case group and 25 cases of paraffin specimens of normal oral mucosa was selected as the the control group. The positive expressions of DKK-1 and MMP-14 were detected via the immunohistochemistry method The relationship between the expressions of DKK-1, MMP-14 and the clinicopathological features of patients with OSCC were analyzed. Results： The positive expression rate of DKK-1 in case group （40.32 %） was significantly lower than that of the control group （68 %）, while the positive expression rate of MMP-14 （72.58 %） was significantly higher than that of the control group （24 %）（P〈0.05）. Both the expressions of DKK-1 and MMP-14 were significantly associated with the malignant degree, lymph node metastasis and differentiation degree of OSCC（P〈0.05）. The DKK-1 protein expression in OSCC tissue was negatively correlated with the MMP-14 protein expression （r=-0.600,P 〈0.05）. Conclusions： The expression of DKK-1 was down-regulated and the expression of MMP-14 was up-regulated in the OSCC, which might be involved in the development and progression of the OSCC and were expected to be used in the assessment of the condition and prognosis assessment of OSCC.

关 键 词：DKK-1 MIMP-14 口腔鳞癌 

分 类 号：R739.8[医药卫生—肿瘤]