苯基吡拉西坦的合成  

Synthesis of phenylpiracetam

作　　者：沈思思 刘九知 陶芳 

机构地区：[1]鞍钢集团公司总医院,鞍山114000 [2]东北制药集团股份有限公司研究院,沈阳110027

出　　处：《中国新药杂志》2017年第19期2340-2342,共3页Chinese Journal of New Drugs

摘　　要：目的:对苯基吡拉西坦的合成方法进行研究。方法:以肉桂酸乙酯为起始原料,经加成、还原、烷基化、氨解,得苯基吡拉西坦。结果:反应收率最高可达40.4%,产品质量合格。结论:该制备方法缩短了合成步骤,简化了操作,提高了产品收率,为神经系统用药苯基吡拉西坦的制备提供了新方法。Objective： To investigate the synthetic technology of phenylpiracetam.Methods： The target compound was synthesized through addition,reduction,alkylation,and ammonolysis from ethyl cinnamate.Results： The reaction yield was up to 40.4%,and the product quality was qualified.Conclusion： This synthetic method has several advantages,such as reduced reaction steps,convenient operation,and the higher yield.It is a new method for the preparation of phenylpiracetam,a central nervous system drug.

关 键 词：苯基吡拉西坦 神经系统用药 合成 

分 类 号：R914[医药卫生—药物化学]