明胶-聚苯胺导电水凝胶的制备与研究  

Properties of electroactive gelatin-graft-polyaniline hydrogel

作　　者：吴天一 卜寿山[1] 庄海[1] 尤莹 张继生[1] 许扬[1] 

机构地区：[1]南京医科大学第一附属医院口腔科,江苏南京210029

出　　处：《南京医科大学学报（自然科学版）》2017年第9期1173-1176,1184,共5页Journal of Nanjing Medical University(Natural Sciences)

基　　金：国家自然科学基金(81670967);江苏省卫生厅面上项目(H201504);江苏省"六大人才高峰"第八批高层次人才项目(WSW-021)

摘　　要：目的 :明胶-聚苯胺接枝共聚物(gelatin-graft-polyaniline,GP)导电水凝胶的制备和性能研究。方法:采用直接掺杂法制作GP,使用樟脑磺酸(camphor sulfonic acid,CSA)作为掺杂剂。GP溶于水形成导电水凝胶(gelatin-graft-polyaniline hydrogel,GPH),以1-(3-二甲氨基丙基)-3-乙基碳二亚胺盐酸盐[1-(3-dimethylaminoproply)-3-ethylcarbodiimide,EDC]进行交联。对制备的GP和GPH的形态结构、生物相容性、溶解性、溶胀比和导电性能进行观察研究。结果:GPH导电性能良好(1×10^(-4)~1×10^(-3)S/cm),并随着苯胺含量的增大而增大。但当苯胺的量提高到一定程度,通过明胶共聚获得的GPH溶解性大大降低,同时溶胀比增加。结论:GPH是一种新型的可降解生物材料,具有良好的导电性能,作为支架在组织工程修复中有巨大的应用前景。Objective： To study the preparation and properties of gelatin-graft-polyaniline （GP） hydrogel.Methods： GP was synthesized by direct doping technique,and camphor sulfonic acid （CSA） was used as dopant.The copolymer was dissolved in water and then cross-linked by EDC.The morphology and chemical feature,swelling ratios,dissolubility,biocompatibility and conductivity of GP hydrogels （GPH） were observed.Results： GPH had good conductivities （1×10~ （-4）~10~ （-3）S/cm）.The electrical property was enhanced with the content of polyaniline.Nonetheless,when the amount of polyaniline improved to a certain degree,the solubility was greatly reduced and swelling ratio was increased at the same time.Conclusion： GPH is a biodegradable conductive material and has great application prospects in tissue engineering.

关 键 词：导电水凝胶 明胶 聚苯胺 

分 类 号：R783.1[医药卫生—口腔医学]