阿朴菲生物碱抗糖尿病生物活性研究进展  

Research Progress in Anti-diabetic Activities of Aporphine Alkaloids

作　　者：刘欣 孙洋[1,2] 窦利民 吴悠楠[2] 谭银丰 董琳 张小坡[2] 

机构地区：[1]哈尔滨商业大学,生命科学与环境科学研究中心,黑龙江哈尔滨150076 [2]海南医学院药学院,海南海口571199

出　　处：《药学进展》2017年第9期704-709,共6页Progress in Pharmaceutical Sciences

基　　金：国家自然科学基金(No.81760628)

摘　　要：糖尿病已成为危害人类健康的主要因素之一。糖尿病药物的研发一直是现代医学领域的热点,天然产物在防治糖尿病方面发挥了积极的作用。阿朴菲生物碱是一类自然界广泛存在的天然产物,现代药理研究发现它们具有抗糖尿病作用。通过检索Pub Med、CNKI等数据库,查阅近年来国内外相关文献,总结了阿朴菲类生物碱对糖尿病及其并发症的生物活性和作用机制,以期为抗糖尿病药物的研究提供参考。Diabetes has been deemed as one of the biggest threats to human health. Development of anti-diabetic drugs has always been a hot field in modern medicine. Natural products have played a very important role in preventing and curing diabetes. Aporphine alkaloids are natural products widely distributed in nature and their anti-diabetic activities have been proved by modern pharmacology. After searching databases like Pubmed and CNKI, we summarized anti-diabetic activities and mechanisms of action of aporphine alkaloids in order to provide references for developing anti- diabetic drugs.

关 键 词：糖尿病 阿朴菲类生物碱 降糖活性 抗糖尿病机制 

分 类 号：R977.15[医药卫生—药品]