过氧化物酶体增殖物激活受体γ 2 rs1801282位点与2型糖尿病肾病易感性的系统评价  

Systematic evaluation of PPAR-γ2 rs1801282 and the susceptibility to type 2 diabetic nephropathy

作　　者：秦林原 张瑛 李友珍 陈晓倩 秦秀妹 文爱珍[4] 罗天圣 刘桂熊 韦丽娜 彭凌湘[5] 于祥远 

机构地区：[1]桂林医学院公共卫生学院流行病学教研室,广西桂林541004 [2]桂林医学院公共卫生学院 [3]桂林医学院第二附属医院,广西桂林541000 [4]桂林市灵川县人民医院,广西桂林541000 [5]桂林医学院第一附属医院,广西桂林541000

出　　处：《现代预防医学》2017年第20期3822-3827,共6页Modern Preventive Medicine

基　　金：广西教育厅高校科研项目(KY2015YB223);教育厅中青年教师基础能力提升项目(KY2016YB310)

摘　　要：目的系统评价PPAR-γ 2基因rs1801282 C>G多态性与2型糖尿病肾病(T2DN)遗传易感性。方法应用PubMed、中国知识资源总库(CNKI)和万方数据库,检索2017年3月前发表的rs1801282多态性与T2DN易感性关联研究。应用Stata 12.0对研究数据统计分析,以合并OR值及相应95%置信区间(95%CI)评价rs1801282与T2DN易感性关系。结果根据纳入、排除标准,纳入16篇病例-对照研究,研究对象9 183例。等位基因比较显示,与rs1801282 C相比,G等位基因可显著降低T2DM患者发生DN的风险,合并效应的OR值及95%CI为0.74(0.62~0.89),P=0.002;以种族进行亚组分析,发现G等位基因与高加索人T2DN发病风险降低有关,OR值及95%CI为0.75(0.60~0.94),P=0.012。基因型分析显示,显性遗传模型(CG+GG vs.CC)下,合并效应的OR值及95%CI为0.72(0.59~0.87),P=0.001;亚组分析发现,rs1801282多态位点与高加索人T2DN遗传易感性有关,OR值及95%CI为0.71(0.56~0.91),P=0.006。结论 PPAR-γ 2基因rs1801282位点与T2DN发病有关,G等位基因可能是机体防止DN发生的保护性遗传因素。Objective To systematically investigate the genetic susceptibility between PPAR-γ2 rs1801282 C 〉G polymorphism and T2DN. Methods PubMed, CNKI and Wanfang data base were searched before March, 2017, for eligible studies. Meta-analysis was performed by using Stata 12.0 software, and OR with corresponding 95%CI were adopted to assess the susceptibility of rs1801282 and T2DN. Results A total of 16 case-control studies with 9 183 subjects were included. Meta-analysis showed that rs1801282 G allele could decrease the risk of T2DM suffering from DN, the OR and corresponding 95%CI were 0.74（0.62 - 0.89）, P=0.002. Subgroup analysis by ethnic showed that rs1801282 was significantly associated with DN in Caucasians, and the OR and 95% CI were 0.75 （0.60 - 0.94）, P=-0.012. Genotype analysis in the dominant model showed that rs1801282 C〉G was significantly associated with T2DN, and the OR and 95%CI were in overall 0.72（0.59 -0.87）, P=0.001, and in Caucasians 0.71 （0.56 -0.91）, P=0.006. Conclusion PPAR-γ2 rs1801282 polymorphism was closely related to the genetic susceptibility to T2DN, and D allele might a protection genetic factor of decrease the risk of T2DM to DN.

关 键 词：PPAR-Γ 2基因 单核苷酸多态性 2型糖尿病肾病 遗传易感性 

分 类 号：R394.3[医药卫生—医学遗传学]