生活习惯造成中西方针刺镇痛效应差异的可能因素:咖啡因  

Possible Living Factors Influencing the Efficacy of Acupuncture Analgesia Between Chinese and Western Populations:Caffeine

作　　者：崔翔[1,2] 刘坤 智沐君[1] 赵亭 何勋 刘昊[3] 高昕妍 朱兵[1] 

机构地区：[1]中国中医科学院针灸研究所,北京100700 [2]湖北中医药大学针灸骨伤学院,武汉430061 [3]乌兰察布市第三医院,内蒙古乌兰察布012000

出　　处：《针刺研究》2017年第5期459-462,共4页Acupuncture Research

基　　金：国家自然科学基金重点项目(No.81130063);国家自然科学基金面上项目(No.81473778);国家自然科学基金青年项目(No.81303054)

摘　　要：疼痛性疾病是针刺治疗的优势病种,但近几年国外关于针刺镇痛临床研究的阴性结果报道,使得人们开始重新思考中、外针刺镇痛有效性结论的歧见。本文从1)咖啡因与疼痛的关系,2)腺苷及其受体与咖啡因,3)针刺镇痛与咖啡因等3个方面分析了咖啡因与中、外针刺镇痛效应差异的可能联系。动物实验结果表明,中等剂量咖啡因可以削弱针刺对小鼠足底切口痛模型的镇痛效应,而咖啡因在多种饮食物中存在,同时也是咖啡的主要成分。在西方,大约有85%以上的成年人有咖啡饮用习惯,因此,笔者旨在围绕咖啡因、腺苷及其受体、针刺镇痛3者之间的关系,探讨咖啡饮用习惯对针刺镇痛效应的可能影响,为分析中、外针刺镇痛效应的疗效差异提供一些思路。It has been known for thousands of years that acupuncture can relieve pain. However, the efficacy of acupuncture analgesia （AA） now has to be reconsidered due to negative reports from western countries. In the present study, the possible correlation between caffeine and the difference in AA in China and western countries was determined using the following factors： 1） caffeine and pain; 2） adenosine, adenosine receptor and caffeine; 3） AA and caffeine. As a non-selective antagonist of the adenosine receptor, caffeine at low doses can be used as an adjuvant analgesic, and can augment antinociception combined with other analgesics. Caffeine can act as an important neural modulator, and adenosine can produce antinociception when combined with the A1 receptor located in spinal, supraspinal and peripheral tissue. A preclinical study demonstrated that caffeine at moderate doses could inhibit AA efficacy following plantar incision surgery in a mouse model. Caffeine is present in various foods, especially coffee, and approximately 85% of adults in western countries consume coffee regularly. Therefore, by reconsidering the correlation between caffeine, adenosine receptor and AA, and by determining the possible relationship between caffeine intake habits and AA efficacy, these findings will demonstrate the differences in AA between Chinese and western populations.

关 键 词：咖啡因 腺苷 A1受体 针刺镇痛 

分 类 号：R246.2[医药卫生—针灸推拿学]