左乙拉西坦治疗难治性癫痫疗效分析及对免疫功能的影响  

Curative Effect of Levetiracetam on Intractable Epilepsy and Its Influence on Immune Function

作　　者：马世江[1] 刘杰[1] 沈长波[1] 靳玫[1] MA Shi-jiang(Department of Neurology, The Third Affiliated Hospital of Xinxiang Medical College, Xinxiang 453003, Henan Province, Chin)

机构地区：[1]新乡医学院第三附属医院神经内科,河南新乡453003

出　　处：《罕少疾病杂志》2017年第5期60-61,67,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的观察左乙拉西坦治疗难治性癫痫疗效分析及对免疫功能的影响。方法选择2013年2月至2016年2月我院收治的难治性癫痫患者100例,按照随机数字表法分为对照组(n=50)和观察组(n=50),对照组给予卡马西平,观察组给予左乙拉西坦,比较两组患者临床疗效、免疫功能及不良反应。结果观察组患者临床总有效率88.00%显著高于对照组70.00%(P<0.05);两组患者治疗后较治疗前CD4+、Ig A、Ig G水平均显著升高(P<0.05),CD8+水平均显著降低(P<0.05);且观察组患者CD4+、Ig A、Ig G水平升高幅度及CD8+水平降低幅度均显著大于对照组(P<0.05);观察组患者不良反应发生率10.00%与对照组12.00%无显著差异(P>0.05)。结论左乙拉西坦治疗难治性癫痫疗效显著,可以提高患者免疫功能。Objective To observe the curative effect of levetiracetam on intractable epilepsy and its influence on immune function. Methods From Feb. 2013 to Feb. 2016, 100 patients with intractable epilepsy in our hospital were randomly divided into control group （n=50） and observation group （n=50）. The control group was given carbamazepine, and the observation group was given levetiracetam. The curative effects, immune function and adverse reactions in the two groups were compared. Results The total effective rate in the observation group was 88% which was significantly higher than that in the control group 70% （P〈0.05）, after treatment, the levels of CD^4＋, IgA and IgG in the two groups were significantly increased （P〈0.05）, but the CD^8＋ levels in the two groups were significantly decreased （P〈0.05）, the increase of CD^4＋, IgA, IgG and decrease of CD^8＋ in the observation group were all significantly higher than those in the control group （P〈0.05）, the incidence rate of adverse reactions in the observation group was 10% which was lower than that in the control group 12%, but their difference was not statistically significant （P〉0.05）. Conclumon Levetiracetam which is effective in the treatment of intractable epilepsy, can improve the immune function of patients.

关 键 词：左乙拉西坦 难治性癫痫 疗效 免疫功能 

分 类 号：R742.1[医药卫生—神经病学与精神病学]